Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy
المؤلفون المشاركون
al-Musawi, Anwar Ghani
al-Hulw, Sabah Ali
al-Kabi, Abd al-Razzaq Hasan
المصدر
العدد
المجلد 17، العدد 1 (30 يونيو/حزيران 2014)، ص ص. 55-61، 7ص.
الناشر
تاريخ النشر
2014-06-30
دولة النشر
العراق
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background: Diabetes mellitus is a condition associated with increased oxidative stress as a consequence of hyperglycemia.
Therefore, the use of antioxidants in people with diabetes has been advocated.
Vitamin E is the most prevalent naturally occurring anti-oxidant.
Aim: To evaluate the effect of the combination of angiotensin receptor blocker (ARB) and vitamin E on urine protein in patients with diabetic nephropathy.
Methods: One hundred and six patients with diabetic nephropathy, who visited the Alsader medical city in Najaf governorate and Al-Furat Al-Awsat general hospital in Kufa, were investigated, 39 of them are type 1diabetics, and 67 of them are type 2 diabetics.
Each patient was followed up for 3 months with valsartan (160mg/day), then for 3 months with addition of tocopherol (400mg).
At the screening visits, proteinuria was determined in two 24 h urine sample, arterial blood pressure was measured twice at ten minutes rest with 2 minutes interval and serum level of potassium, sodium & creatinine were determined.
Results: Proteinuria was significantly lowered when tocopherol 400mg was added to valsartan, as compared with valsartan without tocopherol.
Valsartan alone caused a mean reduction of 24 h urine protein of 27% from the baseline, while the addition of tocopherol caused a mean reduction of 24 hour proteinuria of 30% from result of valsartan.
That is mean the combination therapy of valsartan and tocopherol caused a reduction in proteinuria of 44% from baseline.
Conclusion: The current study suggests that combination therapy of ARB and vitamin E offers an additional antiproteinuric and nephroprotective effect.
Recommendation: Antioxidants, in particular vitamin E have promising nephroprotective effects.
However, studies on other antioxidants like vitamin C are needed in the efforts of prevention of diabetic nephropathy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Kabi, Abd al-Razzaq Hasan& al-Hulw, Sabah Ali& al-Musawi, Anwar Ghani. 2014. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal،Vol. 17, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-790715
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Hulw, Sabah Ali…[et al.]. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal Vol. 17, no. 1 (2014), pp.55-61.
https://search.emarefa.net/detail/BIM-790715
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Kabi, Abd al-Razzaq Hasan& al-Hulw, Sabah Ali& al-Musawi, Anwar Ghani. Nephroprotective effect of vitamin E added to angiotensin receptor blocker in patients with diabetic nephropathy. Kufa Medical Journal. 2014. Vol. 17, no. 1, pp.55-61.
https://search.emarefa.net/detail/BIM-790715
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 59-61
رقم السجل
BIM-790715
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر