دراسة التغيرات المرضية النسجية في ذكور الجرذان البيض المصابة تجريبيا بطفيلي المقوسة الكوندية Toxoplasma gondii

الملخص EN

Toxoplasma gondii is protozoan parasite infected different types of tissues of warm blooded animals and caused toxoplasmosis infection.

Felidae is considered the final host while the rodent, reptiles, birds and mammals including human are the intermediate host.

This study was aimed to isolate T.

gondii from aborted placenta of infected women and experimentally infection of male rats and follow up the histopathological changes that produced in different organs such as brain, heart, liver and testes also we diagnosed the parasite in tissue of this organs.

Thirty male rats Rattus norvegicus (aged (60-70) days averaged weight (200-250gm) used in this study, placed in clean plastic cages and fed on laboratory diet and drinking water), intra-peritoneal infected with suspension of parasite of aborted placenta which prepared by cutting, grinding, filtering and centrifuged of placenta sample.

After 8 weeks of infection the rats were scarified and the organs brain, heart, liver and testes were fixed in 10% formalin for histological processing.

The parasite were noticed and different histopathological changes such as presence of edema and proliferation of astrocytes in brain, while in liver the necrosis of hepatocytes and congestion of central vein and infiltration of inflammatory cells.

In heart there were necrosis and infiltration of inflammatory cells.

In testes there were congestion between the seminiferous tubules and inhibition of spermatogenesis and vaculation of spermatogonia.

This study was recorded the possibility of isolation of T.gondii, noticed the parasite and follow up the histopathological changes in male rats.