دراسة مقارنة بين الكابتوبريل و الليزينوبريل في دورها الوقائي المحتمل من السمية الناجمة عن 5-فلوروبوراسيل في حيوانات التجربة

الملخص EN

Objective: To Compare between Captopril and Lisinopril in their potential protective role in 5-flurouracil- induced Cardiotoxicity, Hepatotoxicity and Nephrotoxicity in Experimental animals.

Method: The current study was conducted in the Department of Pharmacology –UST.

24 adult male rabbits were divided to 4 groups.

The first group was kept as a reference control group given normal saline i.p.

Induction of toxicity was achieved by administration 5FU i.p to the remaining second, third and fourth groups.

At the same time third and fourth group were treated by captopril (0.7mg/kg i.p) and lisinopril (0.1mg/kg i.p) respectively.

All drugs (isotonic solution) were given to experimental animals for 14 days.

Blood samples were collected before and after experiment to measure the biochemical parameters.

Results: The effects of captopril and lisinopril on cardiac, liver and kidney function enzymes after continuous administration of 5FU (10 mg/kg)i.p were measured..

Captopril showed significant reduction in cardiac enzymes from 1168.5±233.0 u/l , 416.4±26.7 u/l in 5FU to 727.83±131.4u/l, 216.9±40.7 u/l for creatine kinase and lactic dehydrogenase respectively in captopril-treated group.

In addition, lisinopril showed significant improvement in cardiac enzymes from 1168.5±233.0 u/l for creatine kinase, 416.4±26.7 u/l for lactic dehydrogenase in 5FU to 464.5±131.5 u/l , 108.7±8.84 u/l in lisinopril-treated group for 14 days.

Lisinopril showed more significant in this respect.

According to hepatoprotective effect both drugs showed insignificant improvement as compared with 5FU-group.

On the other hand, captopril showed nephroprotective effect for kidney as it improved the renal function enzymes from 78.48±4.1mg/dl of creatinine, 1.84±0.163mg/dl of urea in 5FU group to 51.35±6.67mg/dl, 0.687±0.059mg/dl of creatinine and urea respectively in captopril-treated group.

Conclusion: Both drugs showed significant improvement in cardiac enzymes.

Lisinopril was more effective in this respect.

Both drugs showed insignificant hepatoprotective effect, while captopril showed significant nephroprotective effect.

From these results, it was suggested that captopril and lisinopril could be used to prevent toxicity-induced by anticancer drugs.