Formulation of cream and ointment for burns, scars, wounds and diaper rash treatment using natural wheat germ oil

العناوين الأخرى

تحضير كريم و مرهم لمعالجة الحروق و الجروح و آثارها و طفح الحفاض لدى الأطفال باستخدام زيت جنين القمح

مقدم أطروحة جامعية

al-Duri, Raghdah Zakariyya

مشرف أطروحة جامعية

al-Ani, Rad Jabir
al-Wakil, Jabbar Faraj

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

Burn, chronic wounds, scars and diaper rash are health problems that negatively affect the lives of millions of people worldwide.

Wheat germ oil (WGO) is one of the richest natural sources of vitamin E and contains a number of other health-beneficial bioactive compounds, including: polyunsaturated fatty acids, policosanol, squalene, B vitamins, and other mineral content, it is used as dietary supplement and phytosterols (like cholesterol).

Previous studies showed that wheat germ oil has anti- oxidant activity, anti- bacterial activity, which may promote wound healing in experimental animal.

The aim of this study is to assess the effectiveness, safety and cost effectiveness of using wheat germ oil as a cream or ointment formulation for burn, wounds, scars and diaper rash therapy.

Formulation of wheat germ oil as a cream and ointment with two different percentages 10% and 20%.In-vitro evaluation was performed by studying the stability of the final product, and testing the finished products (formulated germ wheat ointment and cream) on induced wounds of ratʼs skin.

This study was performed on male Sprague rats divided into seven groups (four treatment groups each of which four rats compared to three control groups each of which 4 rats).

Burn wound (2cm bottom diameter) was initiated in rats.

The study and follow up were continued for almost 4 weeks.

The result of this study showed significant reduction in both percentage and time for wound healing in the treated groups (10%, 20% wheat germ oil cream and ointment) compared to cold cream & zinc oxide ointment groups and comparable to the control groups.

According the experimental data, this study proofed that topical administration of wheat germ oil in cream and ointment has tremendous therapeutic effect in the treatment of burns, wound, scars, and diaper rush.

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• العلاج
• الحروق
• زيت جنين القمح

عدد الصفحات

80

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-832859