Studying in vivo and in vitro bioavailability of ferrous sulfate and folic acid using of microemulsions as colloidal carriers

العناوين الأخرى

دراسة التوافر في العضوية و في الزجاج لكبريتات الحديد و حمض الفوليك باستخدام المستحلبات الدقيقة كعوامل غيروانية ناقلة

مقدم أطروحة جامعية

al-Duri, Sidq Mustafa Mahdi

مشرف أطروحة جامعية

al-Krad, Jamal al-Yusuf

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2018

الملخص الإنجليزي

The recent advance in drug delivery systems aims to enhance the safety and efficacy of treatment during the formulation of dosage form to be appropriate for the treatment and to achieve the best compliance and acceptance of the patient.

One of these formulations is microemulsion.

Microemulsions are potent drug delivery systems for transdermal application.

Ferrous sulfate and folic acid are usually used in treatment of anemia especially among women.

However, the oral application of ferrous sulfate is associated with low bioavailability, gastrointestinal problems (constipation, flatulence, nausea, unpleasant taste, stomach pain) and food interaction.

The purpose of this study is to evaluation of in vitro and in vivo transdermal bioavailability of ferrous sulfate and folic acid in new developed microemulsions by my college to overcome many problems related with oral dosage form.

Four formulas of FeSO4 7H2O microemulsions were tested in vitro using franz diffusion cell and in vivo.

Also, eight formulas of FA were selected to calculate the flux through the skin using franz diffusion cells and the penetrated amount quantified using HPLC.

S1 (FeSO4 19.2mg) showed the best flux about (0.01303 mg/cm2*h).

Furthermore, in the treated induced anemic rats by applying 0.5 ml of microemulsion over the skin for 28 days show weight and hematocrit (%) improvement and the improvement was proportional to the concentration.

Moreover the formula F3 3.17mg 4S:2T of folic acid microemulsion showed the best flux of )0.01147 mg/cm2*h(.

The developed systems showed good transdermal which candidate them be a good carrier for transdermal application of folic acid and ferrous sulfate

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• كبريتات الحديد

عدد الصفحات

57

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-832880