مستويات الأكسدة و مضاداتها لدى كبار السن من الذكور

الملخص EN

The research included a study of oxidants and antioxidants levels with aging such as: smoking, physical exercise and fasting during Ramadan on elderly by measuring (14) oxidants and antioxidants parameters which included: superoxide dismutase (SOD), glutathione S-transferase (GST), gluconolactonase (senescence marker protein-30) (SMP-30), ceruloplasmin (Cp), albumin, glutathione (GSH), calcium, iron, uric acid, total bilirubin, malondialdehyde (MDA) and peroxynitrite (ONOO-).

The study was carried out on (324) male (age 18 – 95 year) living in Nineveh Governorate The results showed a significant decrease with aging for vitamin C, vitamin E, SMP-30, glutathione(GSH), total bilirubin and calcium, while there was a significant increase of Cp, MDA and peroxynitrite.

The effect of aging (65 year and over) was divided into three groups which showed that the level of oxidative stress was increased with aging, especially in the last group.

The results revealed a significant decrease in the level of: vitamin C, vitamin E, SMP-30, GSH and total bilirubin for smokers with aging compared to non-smokers, while a significant increase of GST, albumin, iron, MDA and peroxynitrite.

Results also showed an increase in oxidants with a decrease in antioxidant compounds with an improvement in the human body by increasing SMP-30, the results revealed a significant decrease for sport training elderly people when compared with non-sport training in vitamin E, GSH and iron, and a significant increase of : GST, SMP-30, Cp and ONOO-.

Moreover, the results showed a significant decrease for aging after fasting in Ramadan for the parameters: GST, Iron, MDA and peroxynitrite and a significant increase for: vitamin C, vitamin E, SOD, SMP-30, Cp, GSH, total bilirubin and calcium, which indicated an improvement in human body for aging with fasting of Ramadan.