Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals

المؤلفون المشاركون

Ikhzaymi, Aishah
Khan, Isra
al-Musawi, Muna A.
Khan, Hasib A.
Sobki, Samiyah H.

المصدر

Saudi Journal of Biological Sciences

العدد

المجلد 25، العدد 8 (31 ديسمبر/كانون الأول 2018)، ص ص. 1729-1732، 4ص.

الناشر

الجمعية السعودية لعلوم الحياة

تاريخ النشر

2018-12-31

دولة النشر

السعودية

عدد الصفحات

4

التخصصات الرئيسية

الأحياء

الموضوعات

الملخص EN

Insulin resistance is a hallmark feature of type-2 diabetes mellitus (T2DM).

We determined the homeostatic model assessment insulin resistance (HOMA-IR) and evaluated its association with C-peptide, insulin, fasting blood glucose (FBG) and glycated hemoglobin (HbA1c) in T2DM patients and non-diabetic subjects.

This study comprised a total of 47 T2DM patients and 38 non-diabetic controls.

Venous blood samples from all the subjects were collected and sera were analyzed for FBG, HbA1c, insulin and Cpeptide using an autoanalyzer.

HOMA-IR was calculated using the following equation: HOMA-IR = fasting insulin (μU/ml) fasting glucose (mmol/L)/22.5.

There was a significant increase in the levels of FBG and HbA1c in diabetic patients.

Although the levels of C-peptide and insulin did not differ significantly between the two groups, a significant increase in HOMA-IR was observed in T2DM patients.

Both insulin and C-peptide were significantly correlated with HOMA-IR.

In conclusion, C-peptide may serve as a simple and convenient predictor of HOMA-IR.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Khan, Hasib A.& Sobki, Samiyah H.& Ikhzaymi, Aishah& Khan, Isra& al-Musawi, Muna A.. 2018. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Ikhzaymi, Aishah…[et al.]. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Khan, Hasib A.& Sobki, Samiyah H.& Ikhzaymi, Aishah& Khan, Isra& al-Musawi, Muna A.. Biomarker potential of C-peptide for screening of insulin resistance in diabetic and non-diabetic individuals. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1729-1732.
https://search.emarefa.net/detail/BIM-835036

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references : p. 1730

رقم السجل

BIM-835036