The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line
المؤلفون المشاركون
Muthanna, Ramzi Ahmad
Abu al-Farah, Muhammad
al-Hamid, Fahd
Alallah, Muhammad Ibrahim
Bai, Fang
al-Shaykh, Muhammad Sulayman
al-Anzi, Khalid Mashai
Ali, Muhammad Ajmal
Lee, Joongku
المصدر
Saudi Journal of Biological Sciences
العدد
المجلد 25، العدد 8 (31 ديسمبر/كانون الأول 2018)، ص ص. 1826-1833، 8ص.
الناشر
تاريخ النشر
2018-12-31
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
The alterations in somatic genomes that controls the mechanism of cell division as a main cause of cancer, and then the drug that specifically toxic to the cancer cells further complicates the process of the development of the widely effective potential anticancer drug.
The side effects of the drug as well as the radiotherapy used for the treatment of cancer is severe; therefore, the search of the natural products from the sources of wild plants having anticancer potential is become immense importance today.
The ethno-medicinal survey undertaken in Al-Fayfa and Wadi-E-Damad region of southern Saudi Arabia revealed that the Caralluma retrospiciens (Ehrenb.) N.E.Br.
(family Apocynaceae) is being used for the treatment of cancer by the native inhabitants.
The biological evaluation of anticancer potential of bioassay-guided fractionations of methanolic extract of whole plant of C.
retrospiciens against human breast adenocarcinoma cell line (MCF-7) followed by characterization using spectroscopic methods confirmed the presence of methyl b-lilacinobioside, a novel active constituent reported for the first time from C.
retrospiciens, is capable of inhibition of cell proliferation and induction of apoptosis in MCF-7 cells by regulating ROS mediated autophagy, and thus validated the folkloric claim.
Based on a small-scale computational target screening, Topoisomerase II was identified as the potential binding target of methyl b-lilacinobioside.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alallah, Muhammad Ibrahim& al-Hamid, Fahd& Bai, Fang& Muthanna, Ramzi Ahmad& al-Shaykh, Muhammad Sulayman& Abu al-Farah, Muhammad…[et al.]. 2018. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences،Vol. 25, no. 8, pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alallah, Muhammad Ibrahim…[et al.]. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences Vol. 25, no. 8 (Dec. 2018), pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alallah, Muhammad Ibrahim& al-Hamid, Fahd& Bai, Fang& Muthanna, Ramzi Ahmad& al-Shaykh, Muhammad Sulayman& Abu al-Farah, Muhammad…[et al.]. The binding proximity of methyl b-lilacinobioside isolated from Caralluma retrospiciens with topoisomerase II attributes apoptosis in breast cancer cell line. Saudi Journal of Biological Sciences. 2018. Vol. 25, no. 8, pp.1826-1833.
https://search.emarefa.net/detail/BIM-835320
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1832-1833
رقم السجل
BIM-835320
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر