Pubertal development and gonadotrophic hormones among girls with type 1 diabetes mellitus
العناوين الأخرى
تطورات البلوغ و وظائف المبيضين في البنات المصابات بالنوع الأول من مرض البول السكري
المؤلفون المشاركون
Hamzah, Rasha Tarif
Nazif, Hiyam kamal
Muhammad, Manar Mahir
Hamid, Amirah Ibrahim
Sharif, Lubna Sayyid
Farid, Samar Muhammad
المصدر
العدد
المجلد 20، العدد 74 (31 يناير/كانون الثاني 2017)، ص ص. 13-18، 6ص.
الناشر
جامعة عين شمس كلية الدراسات العليا للطفولة
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background: As a chronic disease occurring in childhood, type 1 diabetes is a factor potentially affecting the pubertal development, including age at menarche.
Aim of study: To investigate the effect of type 1 diabetes on pubertal development among adolescents; and to investigate their gonadotrophic hormonal profile.
Subjects and Methods: Nineteen Egyptian girls aged (13.8- 21.6) years were recruited into the study.
Assessment of Pubertal development according to Marshall& Tanner (1969) was performed; and age at menarche was evaluated.
Auxological assessment (weight, height, and body mass index) were performed.
Laboratory investigations were done, including HbAlc levels and Hormone assays (basal and post stimulation levels): Scrum follicle- stimulating hormone (FSH), luteinizing hormone (LH), and LH/ FSH ratio was calculated.
Intervention: Girls underwent GnRH- analogue test with triptorelin (0.1 mg) administered subcutaneously.
Results: The mean age at menarche (13.24± 1.25) yrs, among the 17 (89.5%) postmenarchcal TIDM girls, showed no significant difference (P>0.05) from the normal population; but still 2 (10.5%) girls did not achieve menarche until after the study period was terminated.
Moreover, there was a highly significant delay (P< 0.01) in their attainment of adult sexual maturity Tanner stage V (B5, PH5).
Only 3 (15.8%) TIDM girls, had achieved optimal metabolic control, at (< 7.5%), while the remaining 16 (84.2%) had a statistically significant insufficient metabolic control (9.93+ 1.96) (P<0.00).
Also it was found that basal and stimulated LH& FSH levels were significantly decreased in TIDM girls (P<0.000).
Conclusion: Type 1 diabetes could affect pubertal development of girls, in the form of delay in their attainment of adult sexual maturity stages, Tanner Breast stage (B5) and Tanner Pubic Hair development (PH5); however, their age at menarche, is within the range of normal Egyptian girls.
The disease could alter their growth development, with a decrease in their height than the normal population.
LH and FSH were significantly decreased than normal reference ranges.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nazif, Hiyam kamal& Sharif, Lubna Sayyid& Hamzah, Rasha Tarif& Farid, Samar Muhammad& Hamid, Amirah Ibrahim& Muhammad, Manar Mahir. 2017. Pubertal development and gonadotrophic hormones among girls with type 1 diabetes mellitus. Journal of Childhood Studies،Vol. 20, no. 74, pp.13-18.
https://search.emarefa.net/detail/BIM-859487
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nazif, Hiyam kamal…[et al.]. Pubertal development and gonadotrophic hormones among girls with type 1 diabetes mellitus. Journal of Childhood Studies Vol. 20, no. 74 (Jan. 2017), pp.13-18.
https://search.emarefa.net/detail/BIM-859487
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nazif, Hiyam kamal& Sharif, Lubna Sayyid& Hamzah, Rasha Tarif& Farid, Samar Muhammad& Hamid, Amirah Ibrahim& Muhammad, Manar Mahir. Pubertal development and gonadotrophic hormones among girls with type 1 diabetes mellitus. Journal of Childhood Studies. 2017. Vol. 20, no. 74, pp.13-18.
https://search.emarefa.net/detail/BIM-859487
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 17-18
رقم السجل
BIM-859487
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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