دراسة مقارنة لتحريض هرمون النمو بالأنسولين مقابل الكلونيدين عند مرضى فشل النمو في مشفى الأسد الجامعي في اللاذقية

الملخص EN

Background: Short stature is a common cause for medical consultation in pediatrics.

In most cases, it should be evaluated and managed properly.

GH deficiency is one of the endocrinological cause of short stature, which could be managed with GH biosynthesis.

Functional exploration for GH deficiency should be done routinely in case of suspicion of GH deficiency.

Objectives: To compare values of GH with two types of stimulations (Insulin versus Clonidine).

Patients and Methods: 39 patients (3 – 12 years old) with short stature were included in the study.

Provocation tests with Insulin and Clonidine were performed separately under clinical observation.

Results: Fasting GH were all < 7 ng/ml except for one case of Laron syndrome.

The values of peaks and the means of GH were statistically significant P<0.05 (Insulin versus Clonidine).

There was an inverse relationship between the lowest values of glycaemia and the values of GH provoked by Insulin.

ANOVA revealed that the values of GH at (interval 60) is the best among the other times.

Side effects with Insulin were detected in 8 patients (hypoglycemia, tachycardia, pale, perspiration).

Side effects with Clonidine (mild hypotension, lethargy, for few hours in most patients) were de tecded.