Automated reconstruction and manual curation of amino acid biosynthesis pathways in Sulfolobus solfataricus P2
المؤلف
المصدر
Ibn al-Haitham Journal for Pure and Applied Science
العدد
المجلد 32، العدد 3 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-18، 18ص.
الناشر
جامعة بغداد كلية التربية ابن الهيثم
تاريخ النشر
2019-12-31
دولة النشر
العراق
عدد الصفحات
18
التخصصات الرئيسية
الموضوعات
الملخص EN
The efficient sequencing techniques have significantly increased the number of genomes that are now available, including the Crenarchaeon Sulfolobus solfataricus P2 genome.
The genome-scale metabolic pathways in Sulfolobus solfataricus P2 were predicted by implementing the “Pathway Tools” software using MetaCyc database as reference knowledge base.
A Pathway/Genome Data Base (PGDB) specific for Sulfolobus solfataricus P2 was created.
A curation approach was carried out regarding all the amino acids biosynthetic pathways.
Experimental literatures as well as homology-, orthology- and context-based protein function prediction methods were followed for the curation process.
The “PathoLogic” component of the “Pathway Tools” programme was able to predict many amino acid biosynthetic metabolic pathways.
The total number of the metabolic pathways was modified to 168 pathways by adding extra pathways that have not been detected by the “PathoLogic”.
Amino acid biosynthetic pathways such as alpha-aminoadipic acid (AAA) pathway of Lysine biosynthesis and Alanine biosynthesis as well as the super-pathway of Phenylalanine, Tyrosine and Tryptophan biosynthesis variation II were added to the Pathway/Genome data base of Sulfolobus solfataricus P2.
Discovery of the missing enzymes that have to fill in the metabolic holes in the pathways under study was the main curation task.
This approach and the curated amino acid biosynthetic pathways in the PGDB of Sulfolobus solfataricus P2 can be used for genomic annotations and metabolic pathway reconstructions of closely related Bacteria and Archaea.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khayyat, Barzan Ibrahim. 2019. Automated reconstruction and manual curation of amino acid biosynthesis pathways in Sulfolobus solfataricus P2. Ibn al-Haitham Journal for Pure and Applied Science،Vol. 32, no. 3, pp.1-18.
https://search.emarefa.net/detail/BIM-899929
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khayyat, Barzan Ibrahim. Automated reconstruction and manual curation of amino acid biosynthesis pathways in Sulfolobus solfataricus P2. Ibn al-Haitham Journal for Pure and Applied Science Vol. 32, no. 3 (Dec. 2019), pp.1-18.
https://search.emarefa.net/detail/BIM-899929
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khayyat, Barzan Ibrahim. Automated reconstruction and manual curation of amino acid biosynthesis pathways in Sulfolobus solfataricus P2. Ibn al-Haitham Journal for Pure and Applied Science. 2019. Vol. 32, no. 3, pp.1-18.
https://search.emarefa.net/detail/BIM-899929
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 16-18
رقم السجل
BIM-899929
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر