The association of iron and Vitamin B12 status with coronary artery disease in Gaza city

العناوين الأخرى

العلاقة بين حالة الحديد و فيتامين ب12 مع مرض الشريان التاجي في مدينة غزة

مقدم أطروحة جامعية

Shamallakh, Khulud Muhammad Hamid

مشرف أطروحة جامعية

al-Zaharinah, Mazin Midhat

الجامعة

الجامعة الإسلامية

الكلية

كلية العلوم الصحية

دولة الجامعة

فلسطين (قطاع غزة)

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2019

الملخص الإنجليزي

Background: Coronary artery disease (CAD) is an accumulation of atheromatous plaque in medium and large-sized arteries supplying the myocardium.

Iron plays a key role in the maintenance of different cellular functions and mediates various metabolic processes.

Iron overload would increase CAD risk by promoting lipid peroxidation.

Vitamin B12 acts as a co-factor for the methionine synthase enzyme that catalyzes the conversion of homocysteine to methionine.

The lack of vitamin B12 may raise the concentration of homocysteine in plasma which lead to atherosclerosis.

Knowledge of the relationship between iron status, vitamin B12 and CAD may contribute to setting priorities and establishing effective national prevention programs to decrease morbidity and mortality from CAD.

Objective: To investigate the association of iron and vitamin B12 status with coronary artery disease in Gaza city.

Methodology: Case control study was conducted on a sample of 80 persons aged between 30 to 60 years, 40 in each group i.e.

patients with CAD and apparently healthy controls.

Questionnaire interviews were performed among the study population.

Serum ferritin and vitamin B12 were determined using ELISA kits.

Serum iron, lipid profile parameters, high sensitivity C reactive protein (hs-CRP) were determined chemically.

Low destiny lipoprotein (LDL), and body mass index (BMI) were calculated.

Complete blood count (CBC) was also performed.

An approval was acquired from local ethical committee to perform this study.

All data were analyzed by a computer using SPSS program (version 22).

Results: The results showed that the mean level of serum iron in the male cases (71.6  24.7 µg/dl) was lower compared to that of male controls (87.3  28.4 µg/dl) and the difference was statistically significant.

Moreover, transferrin saturation percentage in male cases (24.0 ± 8.9%) was lower compared to male controls (29.0 ± 9.9%) and the difference was statistically significant (p = 0.045).

Additionally, the mean levels of serum vitamin B12 in male cases (238.8 ± 51.4 pg/dl) was lower compared to male controls (337.3± 108.4 pg/dl) and was statistically significant (p<0.001).

The Pearson correlation test showed there was a significant positive correlation between the level of serum iron with the level of vitamin B12 among males but not females (r = 0.28, p = 0.032).

Conclusions: The mean difference of transferrin saturation and serum ferritin between the male cases and male controls was statistically significant.

In contrast, they were no significant difference among female cases and female controls.

The mean levels of serum vitamin B12 in male cases was lower compared to male controls and was statistically significant.

While, the difference was not statistically significant between female cases and female controls.

الموضوع الرئيسي

العلوم الطبية والصيدلة والعلوم الصحية

عدد الصفحات

102

قائمة المحتويات

Table of contents.

Abstract.

Abstract in Arabic.

Chapter One : Introduction.

Chapter Two : Literature review.

Chapter Three : Materials and methods.

Chapter Four : Results.

Chapter Five : Discussion.

Chapter Six : Conclusions and recommendations.

References.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Shamallakh, Khulud Muhammad Hamid. (2019). The association of iron and Vitamin B12 status with coronary artery disease in Gaza city. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-906205

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Shamallakh, Khulud Muhammad Hamid. The association of iron and Vitamin B12 status with coronary artery disease in Gaza city. (Master's theses Theses and Dissertations Master). Islamic University. (2019).
https://search.emarefa.net/detail/BIM-906205

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Shamallakh, Khulud Muhammad Hamid. (2019). The association of iron and Vitamin B12 status with coronary artery disease in Gaza city. (Master's theses Theses and Dissertations Master). Islamic University, Palestine (Gaza Strip)
https://search.emarefa.net/detail/BIM-906205

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-906205