Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats
المؤلفون المشاركون
Shahirudi, Sayyid Murtada Husayni
al-Sadiqbi, Mustafa
Karamian, Roya
Yari, Siamak
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 21، العدد 11 (30 نوفمبر/تشرين الثاني 2019)، ص ص. 1-7، 7ص.
الناشر
تاريخ النشر
2019-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
- الإجهاد التأكسدي
- الألدهيدات
- المواد الكيميائية النباتية
- الجرذان
- المستخلصات النباتية
- المريمية(جنس)
- مضادات الأكسدة
- الكبد الدهني
- السوسن
- بيروكسيد الهيدروجين
الملخص EN
Background: Researchers are interested in finding new agents with natural sources to cure oxidant-induced diseases.
Objectives: The study aimed at determining the antioxidant potential and protective effect of S.
grossheimii extract against alcoholinduced fatty liver.
Methods: This experimental study was performed in Bu-Ali Sina University, Hamedan, Iran.
In 2016 - 2017.
The sample size was determined to include 22 male Wistar rats (150 - 200 g) using Morgan’s table.
In total, 18 rats were divided into three different groups to receive (1) 1 mL water daily (control), (2) 1 mL alcohol daily (alcohol group), and (3) 1 mL extract (500 mg/kg) and alcohol daily (alcohol + extract).
Tissue and blood samples were obtained to determine the protective effect of S.
grossheimii extract against alcoholinduced fatty liver by histological and biochemical examinations.
The antioxidant activity of the extract was also assessed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay.
Results: The extract possessed stronger antiradical activity (IC50: 0.102 0.002 mg/mL) than Vitamin C (IC50: 0.162 0.009 mg/mL).
The histological studies found liver tissue injury in group 2 and biochemical examinations indicated significantly lower (P < 0.05) total protein content (0.2050.002 mg/g.W.t) and superoxide dismutase (42.110.18Uprotein/min) enzymetissue activity than group 1 (TP: 0.236 0.003 mg/g.W.t and SOD: 62.22 0.90).
In addition, the levels of malondialdehyde (MDA) and hydrogen peroxide (H2O2) were significantly higher (P < 0.05) than group 1.
Also, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) serum enzyme levels (314.33 IU/L) were significantly higher (P < 0.05) in alcohol-treated animals than in group 1 (152.33 IU/L).
However, these injuries were remarkably lower (P < 0.05) in animals treated by the extract (group 3).
Conclusions: The results demonstrated the strong pharmaceutical activity of S.
grossheimii extract to apply as a new antioxidant agent, especially for the treatment of fatty liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shahirudi, Sayyid Murtada Husayni& al-Sadiqbi, Mustafa& Karamian, Roya& Yari, Siamak. 2019. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal،Vol. 21, no. 11, pp.1-7.
https://search.emarefa.net/detail/BIM-910602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shahirudi, Sayyid Murtada Husayni…[et al.]. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal Vol. 21, no. 11 (Nov. 2019), pp.1-7.
https://search.emarefa.net/detail/BIM-910602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shahirudi, Sayyid Murtada Husayni& al-Sadiqbi, Mustafa& Karamian, Roya& Yari, Siamak. Phytochemical contents of salvia Grossheimii sosn. species extract and its protective effect on alcohol-induced fatty liver in rats. Iranian Red Crescent Medical Journal. 2019. Vol. 21, no. 11, pp.1-7.
https://search.emarefa.net/detail/BIM-910602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Text in English ; abstracts in .
رقم السجل
BIM-910602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر