Insulin resistance induced by a high fructose diet in rats due to hepatic disturbance
المؤلفون المشاركون
Hibashi, M. I. A.
Mazin, G. M. A.
Kilada, N. A. H.
المصدر
Arab Journal of Nuclear Sciences and Applications
العدد
المجلد 46، العدد 3 (31 يوليو/تموز 2013)، ص ص. 297-306، 10ص.
الناشر
الجمعية المصرية للعلوم النووية و تطبيقاتها
تاريخ النشر
2013-07-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
High consumption of dietary fructose is accused of being responsible for the development of the insulin resistance (IR) syndrome.
Concern has arisen because of the realization that fructose, at elevated concentrations, can promote metabolic changes that are potentially deleterious.
Among these changes is IR which manifests as a decreased biological response to normal levels of plasma insulin.
Therefore, this experiment was designed to evaluate the role of high fructose diet on metabolic syndrome in rats.
The experimental animals were divided into two batches.
The control batch received a control diet; the second batch was given a high-fructose diet as the sole source of carbohydrate.
The rats were continued on the dietary regimen for 1, 2 & 3 months.
After the experimental periods, fructose fed rats groups showed significant elevations in the levels of glucose, insulin sensitivity, liver function tests, nitric oxide and tumor necrosis factor-α when compared to their corresponding values in the rats fed normal diet.
Moreover, liver lipid peroxidation [thiobarbituric acid-reactive substance (TBARS) and lipid hydroperoxide concentrations were remarkably increased in high-fructose-fed rats according to the time of administration (1, 2 &3 months).
On the other hand, the activities of enzymatic antioxidants (glutathione reductase and glutathione peroxidase) and glyoxalase I & II were significantly declined in this group.
In conclusion, high fructose feeding raises liver dysfunction and causes the features of metabolic syndrome (insulin resistance) in rats dependent on the time of administration due to different mechanisms which were discussed in this work according to available recent researches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hibashi, M. I. A.& Mazin, G. M. A.& Kilada, N. A. H.. 2013. Insulin resistance induced by a high fructose diet in rats due to hepatic disturbance. Arab Journal of Nuclear Sciences and Applications،Vol. 46, no. 3, pp.297-306.
https://search.emarefa.net/detail/BIM-934652
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hibashi, M. I. A.…[et al.]. Insulin resistance induced by a high fructose diet in rats due to hepatic disturbance. Arab Journal of Nuclear Sciences and Applications Vol. 46, no. 3 (Jul. 2013), pp.297-306.
https://search.emarefa.net/detail/BIM-934652
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hibashi, M. I. A.& Mazin, G. M. A.& Kilada, N. A. H.. Insulin resistance induced by a high fructose diet in rats due to hepatic disturbance. Arab Journal of Nuclear Sciences and Applications. 2013. Vol. 46, no. 3, pp.297-306.
https://search.emarefa.net/detail/BIM-934652
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 305-306
رقم السجل
BIM-934652
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر