Evaluating the severity of 6-hydroxydopamine induced Parkinson’s disease in diabetic rats

مقدم أطروحة جامعية

Ubayd, Hibah Jabir Subhi

مشرف أطروحة جامعية

Abu Rumaylah, Amjad

الجامعة

جامعة الإسراء

الكلية

كلية الصيدلة

دولة الجامعة

الأردن

الدرجة العلمية

ماجستير

تاريخ الدرجة العلمية

2020

الملخص الإنجليزي

Introduction: Parkinson’s disease and Diabetes Mellitus are both age related diseases.

A debate related to the association between them started in the early sixties.

Today, this possible link is still under study and of interest.

Several studies described that the symptoms of Parkinson’s disease get worse after the onest of Diabetes Mellitus.

Inflammation, mitochondrial dysfunction and oxidative stress are shared pathological mechanisms between neurodegenerative disorders (parkinson’s disease) and diabetes mellitus.

Aim: The aim of this study is to understand the relationship between Parkinson’s disease and diabetes Mellitus.

This may be achieved by examination the ability of 6- OHDA ,which is neurotoxic to damage dopaminergic neurons in presence of diabetes.

Method: Male rats weighing between (220-250) were divided into four groups.

Group A was a control and injected with vehicle only.

Group B animals were given intraperitoneal streptozocin to induce diabetes.

Group C was injected with intracerebral 6-OHDA alone and group D was subjected to 6-OHDA + streptozocin three days before surgery.

The lesion severity was assessd neurochemically and behaviorally.

Result: Fourteen days after intracerebral injection of 6-OHDA and after apomorphine rotation test, 6-OHDA lesioned rats that receive streptozocin showed significantly higher number of rotations in comparison to 6-OHDA alone group.

Additionally, striatal dopamine concentration was lower in 6-OHDA+ streptozocin treated rats versus other groups .

Conclusion: This work suggests that diabetes mellitus accelerate neurodegeneration and put subjects at high risk for Parkinson’

التخصصات الرئيسية

علم الصيدلة

الموضوعات

• مرض باركنسون
• مرضى السكري
• هيدروكسيدوبامين

عدد الصفحات

66

قائمة المحتويات

• APA
• MLA
• AMA

لغة النص

الإنجليزية

نوع البيانات

رسائل جامعية

رقم السجل

BIM-985103