The Role of PPAR-γ and Its Interaction with COX-2 in Pancreatic Cancer

الملخص EN

In recent years, the study of the peroxisome proliferators activated receptor gamma (PPAR-γ) as a potential target for cancer prevention and therapy has gained a strong interest.

However, the overall biological significance of PPAR-γ in cancer development and progression is still controversial.

While many reports documented antiproliferative effects in human cancer cell and animal models, several studies demonstrating potential tumor promoting actions of PPAR-γ ligands raised considerable concerns about the role of PPAR-γ in human cancers.

Controversy also exists about the role of PPAR-γ in human pancreatic cancers.

The current review summarizes the data about PPAR-γ in pancreatic cancer and highlights the biologically relevant interactions between the cyclooxygenase and PPAR system.