Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study
المؤلفون المشاركون
Wang, Xun
Chen, Dafang
Hu, Yonghua
Liang, Mingbin
Fang, Zhian
Wang, Lihua
Yang, Fan
Li, Jin
المصدر
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2009)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-02-22
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Preterm delivery (PTD) is a complicated perinatal adverse event.
We were interested in association of G308A polymorphism in tumor necrosis factor-α (TNF-α) gene with PTD; so we conducted a genetic epidemiology study in Anqing City, Anhui Province, China.
Case families and control families were all collected between July 1999 and June 2002.
To control potential population stratification as we could, all eligible subjects were ethnic Han Chinese.
250 case families and 247 control families were included in data analysis.
A hybrid design which combines case-parent triads and control parents was employed, to test maternal-fetal genotype (MFG) incompatibility.
The method is based on a log-linear modeling approach.
In summary, we found that when the mother's or child's genotype was G/A, there was a reduced risk of PTD; however when the mother's or child's genotype was genotype A/A, there was a relatively higher risk of PTD.
Combined maternal-fetal genotype GA/GA showed the most reduced risk of PTD.
Comparison of the LRTs showed that the model with maternal-fetal genotype effects fits significantly better than the model with only maternal and fetal genotype main effects (log-likelihood = −719.4, P=.023, significant at 0.05 level).
That means that the combined maternal-fetal genotype incompatibility was significantly associated with PTD.
The model with maternal-fetal genotype effects can be considered a gene-gene interaction model.
We claim that both maternal effects and fetal effects should be considered together while investigating genetic factors of certain perinatal diseases.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liang, Mingbin& Wang, Xun& Li, Jin& Yang, Fan& Fang, Zhian& Wang, Lihua…[et al.]. 2010. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988893
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liang, Mingbin…[et al.]. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International No. 2010 (Dec. 2010), pp.1-7.
https://search.emarefa.net/detail/BIM-988893
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liang, Mingbin& Wang, Xun& Li, Jin& Yang, Fan& Fang, Zhian& Wang, Lihua…[et al.]. Association of Combined Maternal-Fetal TNF-α Gene G308A Genotypes with Preterm Delivery: A Gene-Gene Interaction Study. BioMed Research International. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-988893
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-988893
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر