Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine

المؤلفون المشاركون

Schirrmacher, Volker
Fournier, Philippe

المصدر

Journal of Immunology Research

العدد

المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-12-21

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأحياء

الملخص EN

New approaches of therapeutic cancer vaccination are needed to improve the antitumor activity of T cells from cancer patients.

We studied over the last years the activation of human T cells for tumor attack.

To this end, we combined the personalized therapeutic tumor vaccine ATV-NDV—which is obtained by isolation, short in vitro culture, irradiation, and infection of patient's tumor cells by Newcastle Disease Virus (NDV)—with bispecific antibodies (bsAbs) binding to this vaccine and introducing anti-CD3 (signal 1) and anti-CD28 (signal 2) antibody activities.

This vaccine called ATV-NDV/bsAb showed the unique ability to reactivate a preexisting potentially anergized antitumor memory T cell repertoire.

But it also activated naive T cells to have antitumor properties in vitro and in vivo.

This innovative concept of direct activation of cancer patients' T cells via cognate and noncognate interactions provides potential for inducing strong antitumor activities aiming at overriding T cell anergy and tumor immune escape mechanisms.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fournier, Philippe& Schirrmacher, Volker. 2010. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989308

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fournier, Philippe& Schirrmacher, Volker. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research No. 2010 (2010), pp.1-12.
https://search.emarefa.net/detail/BIM-989308

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fournier, Philippe& Schirrmacher, Volker. Tumor Antigen-Dependent and Tumor Antigen-Independent Activation of Antitumor Activity in T Cells by a Bispecific Antibody-Modified Tumor Vaccine. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-12.
https://search.emarefa.net/detail/BIM-989308

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-989308