Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis
المؤلفون المشاركون
Granato, Anna Maria
Petrini, Massimiliano
Verdecchia, Giorgio Maria
Migliori, Giuseppe
Ridolfi, Ruggero
Riccobon, Angela
Ancarani, Valentina
Tauceri, Francesca
Scarpi, Emanuela
Ridolfi, Laura
Pancisi, Elena
Fiammenghi, Laura
Sanna, Stefano
Guidoboni, Massimo
المصدر
Journal of Immunology Research
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We reviewed the clinical results of a dendritic cell-based phase II clinical vaccine trial in stage IV melanoma and analyzed a patient subgroup treated with standard therapies after stopping vaccination.
From 2003 to 2009, 24 metastatic melanoma patients were treated with mature dendritic cells pulsed with autologous tumor lysate and keyhole limpet hemocyanin and low-dose interleukin-2.
Overall response (OR) to vaccination was 37.5% with a clinical benefit of 54.1%.
All 14 responders showed delayed type hypersensitivity positivity.
Median overall survival (OS) was 15 months (95% CI, 8–33).
Eleven patients underwent other treatments (3 surgery, 2 biotherapy, 2 radiotherapy, 2 chemotherapy, and 4 biochemotherapy) after stopping vaccination.
Of these, 2 patients had a complete response and 5 a partial response, with an OR of 63.6%.
Median OS was 34 months (range 16–61).
Our results suggest that therapeutic DC vaccination could favor clinical response in patients after more than one line of therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ridolfi, Laura& Petrini, Massimiliano& Fiammenghi, Laura& Granato, Anna Maria& Ancarani, Valentina& Pancisi, Elena…[et al.]. 2010. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research،Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989313
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ridolfi, Laura…[et al.]. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research No. 2010 (2010), pp.1-9.
https://search.emarefa.net/detail/BIM-989313
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ridolfi, Laura& Petrini, Massimiliano& Fiammenghi, Laura& Granato, Anna Maria& Ancarani, Valentina& Pancisi, Elena…[et al.]. Unexpected High Response Rate to Traditional Therapy after Dendritic Cell-Based Vaccine in Advanced Melanoma: Update of Clinical Outcome and Subgroup Analysis. Journal of Immunology Research. 2010. Vol. 2010, no. 2010, pp.1-9.
https://search.emarefa.net/detail/BIM-989313
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-989313
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر