The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis
المؤلفون المشاركون
Madureira, Patricia A.
Waisman, David M.
Surette, Alexi P.
O'Connell, Paul A.
Miller, Victoria A.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-21، 21ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-14
دولة النشر
مصر
عدد الصفحات
21
التخصصات الرئيسية
الملخص EN
The plasminogen receptors mediate the production and localization to the cell surface of the broad spectrum proteinase, plasmin.
S100A10 is a key regulator of cellular plasmin production and may account for as much as 50% of cellular plasmin generation.
In parallel to plasminogen, the plasminogen-binding site on S100A10 is highly conserved from mammals to fish.
S100A10 is constitutively expressed in many cells and is also induced by many diverse factors and physiological stimuli including dexamethasone, epidermal growth factor, transforming growth factor-α, interferon-γ, nerve growth factor, keratinocyte growth factor, retinoic acid, and thrombin.
Therefore, S100A10 is utilized by cells to regulate plasmin proteolytic activity in response to a wide diversity of physiological stimuli.
The expression of the oncogenes, PML-RARα and KRas, also stimulates the levels of S100A10, suggesting a role for S100A10 in pathophysiological processes such as in the oncogenic-mediated increases in plasmin production.
The S100A10-null mouse model system has established the critical role that S100A10 plays as a regulator of fibrinolysis and oncogenesis.
S100A10 plays two major roles in oncogenesis, first as a regulator of cancer cell invasion and metastasis and secondly as a regulator of the recruitment of tumor-associated cells, such as macrophages, to the tumor site.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Madureira, Patricia A.& O'Connell, Paul A.& Surette, Alexi P.& Miller, Victoria A.& Waisman, David M.. 2012. The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis. BioMed Research International،Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-991650
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Madureira, Patricia A.…[et al.]. The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis. BioMed Research International No. 2012 (2012), pp.1-21.
https://search.emarefa.net/detail/BIM-991650
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Madureira, Patricia A.& O'Connell, Paul A.& Surette, Alexi P.& Miller, Victoria A.& Waisman, David M.. The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-21.
https://search.emarefa.net/detail/BIM-991650
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991650
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر