Comment on “Emerging Functions of Transcription Factors in Malaria Parasite"
المؤلفون المشاركون
Llinás, Manuel
Painter, Heather J.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-2، 2ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-05-20
دولة النشر
مصر
عدد الصفحات
2
التخصصات الرئيسية
الملخص EN
In a recent Journal of Biomedicine and Biotechnology special issue on Immunology and Cell Biology of Parasitic Disease (2011), Tuteja et al.
[1] authored a review summarizing transcription factors in the malaria parasite, Plasmodium.
It is well known that there are very few characterized transcriptional regulators in the malaria parasite [2–4].
To date, the sole family of transcriptional regulators in Plasmodium consists of a conserved group of proteins containing a DNA-interaction domain with high homology to the Arabidopsis APETELA2 (AP2) DNA-binding domain [5].
Related AP2-integrase DNA-binding domains are also present in various Tetrahymena species, a few viruses, and cyanobacteria (reviewed in [6]).
However, there have been no reports of an AP2 expansion in any other eukaryote other than the Apicomplexans.
This lineage-specific expansion is now known as the Apicomplexan AP2 (ApiAP2) protein family [5], and since these proteins represent the first family of putative specific transcriptional regulators in the malaria parasite, their characterization has generated a flurry of recent reports [7–10].
The authors of this review, unfortunately, report an incorrect association between the ApiAP2 proteins (pfam PF00847) and the Activator Protein-2 (AP-2) (pfam PF03299) found in higher eukaryotes (reviewed in [11]).
Despite the similarity in nomenclature, there is absolutely no evolutionary conservation (homology) or functional relationship between the mammalian AP-2 and the malarial ApiAP2 proteins as the authors suggest.
The authors also incorrectly cite a recent in-depth review of the ApiAP2 protein family as a source for this information [12].
As an international journal with a diverse readership, it is pertinent that this misleading information is corrected so as to prevent further confusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Painter, Heather J.& Llinás, Manuel. 2012. Comment on “Emerging Functions of Transcription Factors in Malaria Parasite". BioMed Research International،Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-991878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Painter, Heather J.& Llinás, Manuel. Comment on “Emerging Functions of Transcription Factors in Malaria Parasite". BioMed Research International No. 2012 (2012), pp.1-2.
https://search.emarefa.net/detail/BIM-991878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Painter, Heather J.& Llinás, Manuel. Comment on “Emerging Functions of Transcription Factors in Malaria Parasite". BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-2.
https://search.emarefa.net/detail/BIM-991878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-991878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر