The Isolation of a New S-Methyl Benzothioate Compound from a Marine-Derived Streptomyces sp.

الملخص EN

The application of an HPLC bioactivity profiling/microtiter plate technique in conjunction with microprobe NMR instrumentation and access to the AntiMarin database has led to the isolation of a new 1.

In this example, 1 was isolated from a cytotoxic fraction of an extract obtained from marine-derived Streptomyces sp.

cultured on Starch Casein Agar (SCA) medium.

The 1D and 2D 1H NMR and ESIMS data obtained from 20 μg of compound 1 fully defined the structure.

The known 2 was also isolated and readily dereplicated using this approach.