Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model

المؤلفون المشاركون

Shuid, Ahmad Nazrun
Saadiah Abdul Razak, Halimatun
Isa, N. M.

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-08-09

دولة النشر

مصر

عدد الصفحات

6

التخصصات الرئيسية

الطب البشري

الملخص EN

Androgen-deficient osteoporosis in men is treated with testosterone therapy, which is associated with side effects.

Eurycoma longifolia (EL) is known to possess androgenic properties and has been reported to protect bone from androgen-deficient osteoporosis in experimental animal models.

The present study aimed to determine the effectiveness of combination therapy of EL and testosterone (T) in treating androgen-deficient osteoporosis.

Forty male Sprague-Dawley rats were divided into: sham-operated (SHAM), orchidectomized-control (ORX), orchidectomized with testosterone (ORX + T), orchidectomized with EL (ORX + EL), and orchidectomized with combined T and EL therapy (ORX + T + EL).

EL was administered via oral gavages daily at the dose of 15 mg/kg.

T was injected intramuscularly at 8 mg/kg and 4 mg/kg for the ORX + T and ORX + T + EL groups, respectively.

Following 6 weeks of treatment, the osteocalcin levels of ORX + T and ORX + T + EL groups were significantly lower than the SHAM group (P<0.05).

The posttreatment CTX levels of ORX + T and ORX + T + EL groups were significantly lower than their pretreatment levels (P<0.05).

Biomechanically, the strain parameter of the ORX + T + EL group was significantly higher than the ORX group (P<0.05).

Thus, the combination therapy of EL and low-dose T has potential for treatment of androgen-deficient osteoporosis.

The lower T dose is beneficial in reducing the sideeffects of testosterone therapy.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Saadiah Abdul Razak, Halimatun& Shuid, Ahmad Nazrun& Isa, N. M.. 2012. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992732

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Saadiah Abdul Razak, Halimatun…[et al.]. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-992732

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Saadiah Abdul Razak, Halimatun& Shuid, Ahmad Nazrun& Isa, N. M.. Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-992732

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-992732