Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness
المؤلفون المشاركون
Jia, Qing-An
Ren, Zheng-Gang
Bu, Yang
Wang, Zhi-Ming
Zhang, Qiang-Bo
Liang, Lei
Jiang, Xue-Mei
Zhang, Quan-Bao
Tang, Zhao-You
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-12-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
We investigated the effect of Chinese herbal compound Song-you Yin on HCC stemness.
MHCC97H and Hep3B cell lines were pretreated with SYY for 4 weeks, and their chemosensitivity to oxaliplatin was evaluated.
The expression of CSC-related markers, cell invasion and migration, and colony formation were also examined.
SYY-treated orthotopic nude mouse models of human HCC were developed to explore the effect of oxaliplatin on tumor growth, metastasis, and survival.
The CSC-related molecular changes in vivo were also evaluated.
The result showed that MHCC97H and Hep3B cells pretreated with SYY showed significantly increased chemosensitivity to oxaliplatin and the downregulation of CSC-related markers CD90, CD24, and EPCAM.
SYY also attenuated cell motility, invasion, and colony formation in MHCC97H and Hep3B cell lines.
The reduced tumorigenicity and pulmonary metastasis were observed in SYY-pretreated cell lines.
Combination treatment with oxaliplatin and SYY significantly reduced tumor volume and pulmonary metastasis and prolonged survival compared with oxaliplatin treatment alone.
Immunohistochemical analysis showed reduced expression of CD90, ABCG2, ALDH, CD44, EPCAM, vimentin, and MMP-9 and increased the expression of E-cadherin, in HCC cells following combination treatment.
These data clearly demonstrate that SYY renders hepatocellular carcinoma sensitive to oxaliplatin through the inhibition of stemness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jia, Qing-An& Ren, Zheng-Gang& Bu, Yang& Wang, Zhi-Ming& Zhang, Qiang-Bo& Liang, Lei…[et al.]. 2012. Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992763
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jia, Qing-An…[et al.]. Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-992763
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jia, Qing-An& Ren, Zheng-Gang& Bu, Yang& Wang, Zhi-Ming& Zhang, Qiang-Bo& Liang, Lei…[et al.]. Herbal Compound “Songyou Yin” Renders Hepatocellular Carcinoma Sensitive to Oxaliplatin through Inhibition of Stemness. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-992763
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992763
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر