Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis
المؤلفون المشاركون
Shuid, Ahmad Nazrun
Fathilah, Siti Noor
Abdullah, Shahrum
Mohamed, Norazlina
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis.
However, ERT causes serious side effects, such as cancers and thromboembolic problems.
Labisia pumila var.
alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures.
This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model.
Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var.
alata (LP), and ovariectomized with ERT (Premarin) (ERT).
The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 μg/kg, respectively.
Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing.
The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength.
Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. 2012. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fathilah, Siti Noor…[et al.]. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992807
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-992807
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر