Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis

المؤلفون المشاركون

Shuid, Ahmad Nazrun
Fathilah, Siti Noor
Abdullah, Shahrum
Mohamed, Norazlina

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-7، 7ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-09-09

دولة النشر

مصر

عدد الصفحات

7

التخصصات الرئيسية

الطب البشري

الملخص EN

Estrogen replacement therapy (ERT) is the main treatment postmenopausal osteoporosis.

However, ERT causes serious side effects, such as cancers and thromboembolic problems.

Labisia pumila var.

alata (LPva) is a herb with potential as an alternative to ERT to prevent complications of osteoporosis, especially fragility fractures.

This study was conducted to determine the effects of LPva on the biomechanical strength of femora exposed to osteoporosis due to estrogen deficiency, using the postmenopausal rat model.

Thirty-two female rats were randomly divided into four groups: Sham-operated (Sham), ovariectomized control (OVXC), ovariectomized with Labisia pumila var.

alata (LP), and ovariectomized with ERT (Premarin) (ERT).

The LPva and ERT were administered via oral gavage daily at doses of 17.5 mg/kg and 64.5 μg/kg, respectively.

Following two months of treatment, the rats were euthanized, and their right femora were prepared for bone biomechanical testing.

The results showed that ovariectomy compromised the femoral strength, while LPva supplementation to the ovariectomized rats improved the femoral strength.

Therefore, LPva may be as effective as ERT in preventing fractures due to estrogen-deficient osteoporosis.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. 2012. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Fathilah, Siti Noor…[et al.]. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-992807

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Fathilah, Siti Noor& Abdullah, Shahrum& Mohamed, Norazlina& Shuid, Ahmad Nazrun. Labisia pumila Prevents Complications of Osteoporosis by Increasing Bone Strength in a Rat Model of Postmenopausal Osteoporosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-992807

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-992807