Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL
المؤلفون المشاركون
Xie, Huimin
Wang, Ruiqing
Huang, Zhaofeng
Shang, Weirong
Sun, Zuoming
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-12-26
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Survival of T cells in both the central and peripheral immune system determines its ultimate function in the regulation of immune responses.
In the thymus, developing T cells undergo positive and negative selection to generate a T cell repertoire that responds to foreign, but not self, antigens.
During T cell development, the T cell receptor α chain is rearranged.
However, the first round of rearrangement may fail, which triggers another round of α chain rearrangement until either successful positive selection or cell death occurs.
Thus, the lifespan of double positive (CD4+CD8+; DP) thymocytes determines how many rounds of α chain rearrangement can be carried out and influences the likelihood of completing positive selection.
The anti-apoptotic protein Bcl-xL is the ultimate effector regulating the survival of CD4+CD8+ thymocytes subject to the selection process, and the deletion of Bcl-xL leads to premature apoptosis of thymocytes prior to the completion of the developmental process.
In addition to its critical function in the thymus, Bcl-xL also regulates the survival of peripheral T cells.
Upon engagement with antigens, T cells are activated and differentiated into effectors.
Activated T cells upregulate Bcl-xL to enhance their own survival.
Bcl-xL-mediated survival is required for the generation of effectors that carry out the actual immune responses.
In the absence of Bcl-xL, mature T cells undergo apoptosis prior to the completion of the differentiation process to become effector cells.
Therefore, Bcl-xL ensures the survival of both developing and peripheral T cells, which is essential for a functional immune system.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ruiqing& Xie, Huimin& Huang, Zhaofeng& Shang, Weirong& Sun, Zuoming. 2011. Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994557
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ruiqing…[et al.]. Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-994557
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ruiqing& Xie, Huimin& Huang, Zhaofeng& Shang, Weirong& Sun, Zuoming. Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL. Journal of Immunology Research. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-994557
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-994557
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر