Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model
المؤلفون المشاركون
Kadowaki, Makoto
Yamamoto, Takeshi
Kodama, Toshihisa
Tsubota, Yuma
Kageyama-Yahara, Natsuko
المصدر
Journal of Immunology Research
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-15
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
We examined whether maternal exposure to food antigens during lactation and maternal allergic status would affect the development of food allergy in offspring.
OVA-sensitized or OVA-nonsensitized BALB/c female mice were exposed or unexposed to OVA during lactation.
After weaning, their offspring were systemically sensitized twice with OVA and repeatedly given OVA by oral intubation.
While 97.1% of the mice breastfed by OVA-nonsensitized and OVA-unexposed mothers developed allergic diarrhea, 59.7% of the mice breastfed by OVA-exposed nonallergic mothers during lactation and 24.6% of the mice breastfed by OVA-exposed allergic mothers during lactation developed food allergy.
Furthermore, OVA was detected in breast-milk from OVA-exposed nonallergic mothers during lactation (4.6±0.5 μg/mL).
In addition, OVA-specific IgG1 titers were markedly increased in breast milk from allergic mothers (OVA-sensitized and OVA-unexposed mother: 11.0±0.5, OVA-sensitized and OVA-exposed mother: 12.3±0.3).
Our results suggest that oral tolerance induced by breast milk-mediated transfer of dietary antigens along with their specific immunoglobulins to offspring leads to antigen-specific protection from food allergy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yamamoto, Takeshi& Tsubota, Yuma& Kodama, Toshihisa& Kageyama-Yahara, Natsuko& Kadowaki, Makoto. 2012. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996799
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yamamoto, Takeshi…[et al.]. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research Vol. 2012, no. 2012 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-996799
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yamamoto, Takeshi& Tsubota, Yuma& Kodama, Toshihisa& Kageyama-Yahara, Natsuko& Kadowaki, Makoto. Oral Tolerance Induced by Transfer of Food Antigens via Breast Milk of Allergic Mothers Prevents Offspring from Developing Allergic Symptoms in a Mouse Food Allergy Model. Journal of Immunology Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-996799
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-996799
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر