Evaluation of immune response in children vaccinated against measles, mumps and rubella : a meta-analysis of Egyptian studies in the last ten years

Abstract EN

Background: Mumps, measles and rubella are serious infections that can lead to potentially fatal illness, disability and death.

However, public debate over the safety of the vaccine despite it is almost universal use and accepted effectiveness.

Measles is the next target for ersdication.

Mumps, measles and rubella (MMR) vaccine is a mixture of live attenuated viiuses of the three diseases.

The MMR vaccine is administered to children around the age of one year, with a second dose before starting school.

Meta- analysis is an epidemiological technique for summarizing and reviewing previous quantitative research, by using meta- analysis.

Objective: to evaluate the persistence of protective serum antibodies level of measles, mumps and rubella in vaccinated children and to assess the efficacy of vaccination programs.

Also, to provide the first meta- analysis that studies the immune response of meales- mumps& rubella vaccine in healthy vaccinated children.

Methodology: The researcher reviewed the Egyptian thieses, papers, journals, in English language, searching for the eligible studiespublished in the last ten years.

Meta- analysis was done using MedCalc software ver.

12.7.7.0.

Results: The proportion of seroprotected healthy vaccinated Egyptian children with measles antibodies is 80.74%.

The proportion of seroprotected Egyptian children with mumps antibodies is 45.06%.

The proportion of seroprotected Egyptian children with rubella antibodies is 90.21%.

Conclusion: The proportion of seroprotected Egyptian children aged from 3-18 years with measles, mumps, rubella vaccinated children is lower than most of the other studies in other countries.

The vaccine used is live attenuated vaccine, in Egypt only Sanofi Pasteur and GSK, Belgium are registered.

Recommendations: Further studies need to be done in order to assess the efficacy of vaccination programs regarding measles, mumps and rubella and factors affecting the antibodies’ level