Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens
Joint Authors
Harb, Hani
Alashkar Alhamwe, Bilal
Acevedo, Nathalie
Frumento, Paolo
Johansson, Catharina
Eick, Lisa
Alm, Johan
Potaczek, Daniel P.
Scheynius, Annika
Renz, Harald
Papadogiannakis, Nikos
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Prenatal environmental exposures are considered to contribute to the development of allergic sensitization by epigenetic mechanisms.
The role of histone acetylation in the placenta has not been examined yet.
We hypothesized that placental histone acetylation at the promoter regions of allergy-related immune regulatory genes is associated with the development of sensitization to allergens in the child.
Histones H3 and H4 acetylation at the promoter regions of 6 selected allergy-related immune regulatory genes was assessed by a chromatin immunoprecipitation assay in 173 term placentas collected in the prospective birth-cohort ALADDIN.
The development of IgE sensitization to allergens in the children was followed from 6 months up to 5 years of age.
We discovered significant associations of histone acetylation levels with decreased risk of allergic sensitization in 3 genes.
Decreased risk of sensitization to food allergens was associated with higher H3 acetylation levels in placentas at the IFNG and SH2B3 genes, and for H4 acetylation in HDAC4.
Higher HDAC4 H4 acetylation levels were also associated with a decreased risk of sensitization to aeroallergens.
In conclusion, our results suggest that acetylation of histones in placenta has a potential to predict the development of sensitization to allergens in children.
American Psychological Association (APA)
Harb, Hani& Alashkar Alhamwe, Bilal& Acevedo, Nathalie& Frumento, Paolo& Johansson, Catharina& Eick, Lisa…[et al.]. 2019. Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens. BioMed Research International،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123267
Modern Language Association (MLA)
Harb, Hani…[et al.]. Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens. BioMed Research International No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1123267
American Medical Association (AMA)
Harb, Hani& Alashkar Alhamwe, Bilal& Acevedo, Nathalie& Frumento, Paolo& Johansson, Catharina& Eick, Lisa…[et al.]. Epigenetic Modifications in Placenta are Associated with the Child’s Sensitization to Allergens. BioMed Research International. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1123267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1123267