Postmortem tissue distribution of citalopram in a case of carbon monoxide poisoning
Other Title(s)
توزيع عقار السيتالوبرام في الأنسجة بعد الوفاة في حالة التسمم بأول أكسيد الكربون
Joint Authors
Attafi, Ibrahim M.
al-Bishi, Muhammad Yahya
Uraybi, Majbul E.
Khawaji, Muhammad al-Badr M.
Arishi, Muhammad A.
Source
Arab Journal of Forensic Sciences and Forensic Medicine
Issue
Vol. 2, Issue 1 (30 Jun. 2020), pp.75-79, 5 p.
Publisher
Naif Arab University for Security Sciences Arab Society for Forensic Sciences and Forensic Medicine
Publication Date
2020-06-30
Country of Publication
Saudi Arabia
No. of Pages
5
Main Subjects
Abstract EN
Citalopram abuse may impair judgment and increase the risk of suicidal thoughts.
This case report aims to study the postmortem tissue distribution of citalopram in a case of carbon monoxide poisoning.
Initial analysis was done by both immunoassay and non-targeted GC-MS screening methods.
Carbon monoxide was identified and quantified by measuring the carboxyhemoglobin levels in spleen secretion (black bile) and spleen blood using a UV-visible spectrophotometer, while citalopram was identified and quantified by using an LC-MS-MS system.
Initial analysis showed that citalopram was present in all samples determined by immunoassay.
The results of carboxyhemoglobin analysis were 85% in the spleen secretion and spleen blood, which are generally fatal levels.
The results of LC-MS-MS showed that citalopram concentrations were 0.58 mg/L, 0.37 mg/L, 0.29 mg/L, 0.13 mg/L, 0.10 mg/L, and 0.01 mg/L, in the spleen blood, brain, spleen, kidney, liver and stomach, respectively.
The highest concentrations of citalopram, 0.58 mg/L and 0.37 mg/L, were detected in spleen blood and brain tissue, respectively, which could be used as an alternative specimen to blood.
American Psychological Association (APA)
Uraybi, Majbul E.& al-Bishi, Muhammad Yahya& Khawaji, Muhammad al-Badr M.& Arishi, Muhammad A.& Attafi, Ibrahim M.. 2020. Postmortem tissue distribution of citalopram in a case of carbon monoxide poisoning. Arab Journal of Forensic Sciences and Forensic Medicine،Vol. 2, no. 1, pp.75-79.
https://search.emarefa.net/detail/BIM-1277715
Modern Language Association (MLA)
Attafi, Ibrahim M.…[et al.]. Postmortem tissue distribution of citalopram in a case of carbon monoxide poisoning. Arab Journal of Forensic Sciences and Forensic Medicine Vol. 2, no. 1 (Jun. 2020), pp.75-79.
https://search.emarefa.net/detail/BIM-1277715
American Medical Association (AMA)
Uraybi, Majbul E.& al-Bishi, Muhammad Yahya& Khawaji, Muhammad al-Badr M.& Arishi, Muhammad A.& Attafi, Ibrahim M.. Postmortem tissue distribution of citalopram in a case of carbon monoxide poisoning. Arab Journal of Forensic Sciences and Forensic Medicine. 2020. Vol. 2, no. 1, pp.75-79.
https://search.emarefa.net/detail/BIM-1277715
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1277715