Effect of some plant parts powder on obesity complications of obese rats

الملخص EN

The present study aims to investigate the effectiveness of some plant parts powder on obesity complications induced in experimental animals.

Thirty male albino rats (150 ± 10g), were divided into two main groups, the first group (6 rats) still fed on basal diet and the other main group (contained 25 rats classified into five sub groups as follow: Group (2) fed on DIO (diet induced obesity) as a positive control; groups ( from 3 to 6) fed on DIO containing 5% cauliflower leaves powder (CLP), mulberry leaves powder (MLP), pomegranates peel powder (PPP) and their mixture, respectively.

The results stated that feeding on DIO leads to increase the BWG than the control group.

At the end of the experiment (8 weeks), rats of the obese group recorded increasing rate 53.75 % of baseline.

Replacement of carbohydrates diet with CLP, MLP, PPP and their mixture induced significant decreasing on BWG of the obese rats which recorded 31.26, 20.98, 7.49 and 5.68% of baseline, respectively.

Biochemical analysis data indicated that obesity induced a significant increase in liver functions (28.99% , 30.82% and 29.61% U/L) as AST, ALT and ALP respectively.

For serum lipid profile recorded (38 % mg/dlTG, 33.71 % mg/dl TC, 82.98 % mg/dl LDL-c and 38 % mg/dl VLDL, ), serum glucose (29.91% ) and MDA (Malonaldehyde, biomarker of serum lipid oxidation, 23.96 % ) compared to normal control.

Feeding on 5% of CLP, MLP, PPP and their mixture exhibited a significant improvement (p≤0.05) in all of these parameters by different rates.

The higher amelioration effects were recorded for the plant parts mixtures treatment followed by PPP, MLP and CLP.

In conclusion, the present study has demonstrated the potency of plant parts including CLP, MLP, PPP and their mixture to ameliorate liver disorder and hyperglycemia in obese rats.

Furthermore, CLP, MLP, PPP and their mixture lowered serum lipid peroxidation (malonaldehyde, MDA) levels and inflammatory stress in liver.

These findings provide a basis for the use of CLP, MLP, PPP and their mixture for the prevention and early treatment of obesity and its complications.