Biochemical and Histopathological Effects Induced by Methimazole in Rats Treated by vitamin C
Joint Authors
Hindi, Muhammad Husayn
al-Saffar, Ali Husayn Ali
Ali, Sabirin Majid Muhammad
Source
Journal of Thi-Qar University for Agricultural Researches
Issue
Vol. 11, Issue 2 (31 Dec. 2022), pp.234-241, 8 p.
Publisher
University of Thi-Qar College of Agricultural and Marshes
Publication Date
2022-12-31
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Abstract EN
In order to investigate some biochemical and histopathological changes effects of Methimazole (ME)in rats twenty eight white female rats were equally divided into four target groups, (ME) The 1 group, was given sterile saline (0.9%) and served as a control (c).
The 2nd group, was given Methimazole at dose 0.04 mg/kg B.W.
orally (positive control).
The 3rd group, was given Methimazole at dose 0.04 mg/kg B.W.
and Vitamin C 200 mg/kg B.W.
orally.
The 4th group, was given only Vitamin C 200 mg/kg B.W.
orally.
Results aimed in the present study on the effect of Methimazole at daily intake doses to investigate possible adverse effects and modulate its possible mechanism by measuring the oxidant and antioxidant impact in brain and Ameliorative trail of vit.
C.
Vit C antioxidant, such as super oxide, increase super oxide elimination, examination revealed that the (ME) histopathological figures showed very small size thyroid gland that displayed atrophy, composed numerous small size follicles with normal follicular cells and C-cells.
Study concludes, (vit c) can decreased thyroid damage caused by oxidative effects triggered by (ME) and linked to their antioxidant effects.
American Psychological Association (APA)
Hindi, Muhammad Husayn& Ali, Sabirin Majid Muhammad& al-Saffar, Ali Husayn Ali. 2022. Biochemical and Histopathological Effects Induced by Methimazole in Rats Treated by vitamin C. Journal of Thi-Qar University for Agricultural Researches،Vol. 11, no. 2, pp.234-241.
https://search.emarefa.net/detail/BIM-1513615
Modern Language Association (MLA)
Hindi, Muhammad Husayn…[et al.]. Biochemical and Histopathological Effects Induced by Methimazole in Rats Treated by vitamin C. Journal of Thi-Qar University for Agricultural Researches Vol. 11, no. 2 (2022), pp.234-241.
https://search.emarefa.net/detail/BIM-1513615
American Medical Association (AMA)
Hindi, Muhammad Husayn& Ali, Sabirin Majid Muhammad& al-Saffar, Ali Husayn Ali. Biochemical and Histopathological Effects Induced by Methimazole in Rats Treated by vitamin C. Journal of Thi-Qar University for Agricultural Researches. 2022. Vol. 11, no. 2, pp.234-241.
https://search.emarefa.net/detail/BIM-1513615
Data Type
Journal Articles
Language
English
Notes
Includes appendices : p. 241
Record ID
BIM-1513615