Comparison of Moringa oleifera leaves extract with atenolol on serum triglyceride, serum cholesterol, blood glucose, heart weight, body weight in adrenaline induced rats

Abstract EN

The research work was investigated to compare the effects of Moringa oleifera with atenolol on serum cholesterol level, serum triglyceride level, blood glucose level, heart weight and body weight of adrenaline induced rats (AIR) in a crossover design.

The pharmacologically active components responsible for above-mentioned activities were isolated from plant using bioassay guided purification approach and the structures of the compounds were proposed by the spectroscopic methods.

Moringa oleifera leaves extract and commercial drug atenolol were administered in adrenaline induced rat through intraperitoneal (i.p) route in everyday morning for one week at a dose 30mg/155±15-gm.body weight and 0.1 mg/155±15-gm.body weight of rat respectively.

Different biochemical parameters such as heart weight, blood glucose level, serum cholesterol level, serum triglyceride level, body weight and the relationship between them were measured.

The dose of the marketed drug atenolol was determined according to the previous knowledge of its pharmacokinetic parameters.

Clinically effective plasma concentration as a hypotensive drug was obtained after the injection of 0.1 mg /155±5 gm body weight of drug.

The Moringa oleifera leaves extract made significant changes in each cardiovascular parameter after proper investigation.

From the present study we revealed that the leaves extracts of Moringa oleifera with atenolol has got profound hypolipidemic (Figure 3) activity.

Lowering of blood glucose, heart weight, and body weight (Figure 1,2 and 4) in adrenaline induced rats (.

p<0.0001) was significant.

The lowering serum triglyceride level and serum cholesterol level between leaves extract of Moringa oleifera and atenolol in adrenaline induced rats was very significant (p<0.001 & p<0.01).