التأثير السمي الوراثي لمبيد القوارض (البروديفاكوم)‎ في الخلايا المولدة للنطف و الخلايا الأمية للبيوض في الفئران

Abstract EN

In this study three doses of rodenticide brodifacoum have been investigated for the frequency of chromosomal aberrations in metaphase 1 chromosomes recovered from oocytes was compared with those recoverd from spermatocytes in pachytene and diplotene phases.

The results showed no affect appears in oocytes and spermatocytes after one day, but it was effected in 7, 21, 35 day after treatment.

These doses induced singnificantly higher chromosomal aberration specially after 21 and 35 day.

The frequency of aberration in oocytes did not differ in spermatocytes during diplotene, but significantly more chromosome aberrations were found in pachyten phase compared with those in diplotene.

The pachytene is more sensitive to rodenticide.

Increased chromosomal aberration especially after 21, 35 day.

Conclusion of these tests were revealed that the brodifacoum had a significant cytogenetic and genotoxic effects.

These effects were more in spermatocytes than oocytes.