Expression of SSX-1 and SSX-5 genes in the peripheral blood of patients with hepatocellular carcinoma
Joint Authors
Muawwad, Muhammad
Fawzi, Amal
Fawzi, Nifin
Zahir, Amr al-Sayyid
Jumah, Asma I.
Abd Allah, Ayah R.
Youakim, Majdi Fuad
Source
The Egyptian Journal of Medical Human Genetics
Issue
Vol. 15, Issue 1 (31 Jan. 2014), pp.45-51, 7 p.
Publisher
Egyptian Society of Human Genetics
Publication Date
2014-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Liver cancer is the fifth most common cancer in men and the seventh in women.
Hepatocellular carcinoma (HCC) is responsible for significant morbidity and mortality in patients with liver cirrhosis and accounts for 90 % of primary liver cancer.
Synovial sarcoma X chromosome (SSX) genes belong to cancer testis antigens (CTA) family ; expressed only in germ cell tumors.
There have been some studies about the SSX genes expression in the HCC.
To the best of our knowledge no reports included these genes expression in the Egyptian patients with HCC.
Aim : This study aims to evaluate the SSX-1 and SSX-5 mRNA expression in tumor cells circulating in the peripheral blood (PB) of a cohort of Egyptian patients with HCC and to find out any possible associations between these genes expression and different clinical / laboratory parameters.
Subjects and methods : This study included 100 subjects ; 52 HCC cases, 25 with post viral hepatitis liver cirrhosis and 23 apparently healthy controls.
Expression of SSX-1 and SSX-5 mRNA in PB was tested by reverse transcription polymerase chain reaction (RT-PCR).
American Psychological Association (APA)
Fawzi, Amal& Fawzi, Nifin& Zahir, Amr al-Sayyid& Jumah, Asma I.& Abd Allah, Ayah R.& Muawwad, Muhammad…[et al.]. 2014. Expression of SSX-1 and SSX-5 genes in the peripheral blood of patients with hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics،Vol. 15, no. 1, pp.45-51.
https://search.emarefa.net/detail/BIM-360573
Modern Language Association (MLA)
Muawwad, Muhammad…[et al.]. Expression of SSX-1 and SSX-5 genes in the peripheral blood of patients with hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics Vol. 15, no. 1 (Jan. 2014), pp.45-51.
https://search.emarefa.net/detail/BIM-360573
American Medical Association (AMA)
Fawzi, Amal& Fawzi, Nifin& Zahir, Amr al-Sayyid& Jumah, Asma I.& Abd Allah, Ayah R.& Muawwad, Muhammad…[et al.]. Expression of SSX-1 and SSX-5 genes in the peripheral blood of patients with hepatocellular carcinoma. The Egyptian Journal of Medical Human Genetics. 2014. Vol. 15, no. 1, pp.45-51.
https://search.emarefa.net/detail/BIM-360573
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 50-51
Record ID
BIM-360573