A facile synthesis and biological study of tri-[4-(5-aryl-1,3,4-oxadiazol-2-yl)phenyl]phosphate
Joint Authors
Hamid, Iyad Sadi
Ali, Radwan M.
Yusuf, Imad A.
Source
Issue
Vol. 2005, Issue 19 (30 Sep. 2005), pp.412-425, 14 p.
Publisher
University of Babylon College of Sciences
Publication Date
2005-09-30
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Topics
Abstract EN
In the present investigation, nine novel 2-(aryl)-5-[4-(aroyloxy)phenyl]-1,3,4-oxadiazoles [2-10] were synthesized by a facile one step method through the reaction of 4-hydroxybenzoyl hydrazine with two equivalent of appropriate acid in the presence of phosphorus oxychloride.
Three novel phosphate esters containing three 1,3,4-oxadiazole units [14-16], namely {tri-[4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl]phosphate [14], tri-[4-(5-(p-methoxy phenyl)-1,3,4-oxadiazol-2-yl)phenyl]phosphate [15] and tri-[4-(5-(p-nitro phenyl)-1,3,4-oxadiazol-2-yl)phenyl]phosphate [16]} were also synthesized by one step method through condensation of three equivalent of phenolic compounds [11-13] with phosphorus oxychloride.
All the synthesized compounds were characterized by their melting points and spectral (FT-IR, mass, CHN and UV) data.
The newly synthesized compounds were subjected to in vitro against two strains of pathogenic microorganism viz., Staphylococcus arueus and Escherichia coli.
The results obtained revealed that compounds [15 and 16] showed considerable activity against Escherichia coli.
American Psychological Association (APA)
Hamid, Iyad Sadi& Yusuf, Imad A.& Ali, Radwan M.. 2005. A facile synthesis and biological study of tri-[4-(5-aryl-1,3,4-oxadiazol-2-yl)phenyl]phosphate. National Journal of Chemistry،Vol. 2005, no. 19, pp.412-425.
https://search.emarefa.net/detail/BIM-362372
Modern Language Association (MLA)
Hamid, Iyad Sadi…[et al.]. A facile synthesis and biological study of tri-[4-(5-aryl-1,3,4-oxadiazol-2-yl)phenyl]phosphate. National Journal of Chemistry No. 19 (2005), pp.412-425.
https://search.emarefa.net/detail/BIM-362372
American Medical Association (AMA)
Hamid, Iyad Sadi& Yusuf, Imad A.& Ali, Radwan M.. A facile synthesis and biological study of tri-[4-(5-aryl-1,3,4-oxadiazol-2-yl)phenyl]phosphate. National Journal of Chemistry. 2005. Vol. 2005, no. 19, pp.412-425.
https://search.emarefa.net/detail/BIM-362372
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 425
Record ID
BIM-362372