Synthesis and antimicrobial activity of some (2-amino-5-thiol-1, 3, 4-thiadiazole derivatives

Abstract EN

Five derivatives of thiadiazole were prepared with aldehydes and alkyl halides, compoundA: 2-amino-5-thiol-1,3,4- thiadiazole, compound B :2-(o-hydroxybenzylidine)amino-5-thiol-1,3,4-thiadiazole, compoundC: 2(2-butan-lidine)amino-5-thiol-1,3,4-thiadiazole, compound E: 2- amino-5-(2-Propanylthio)-1,3,4-thiadiazol) and compound F : 2(o-chlorobenzylamino)-5-(2-propanyl thio)-1,3,4 thiadiazol.

All prepared compounds were diagnosed by (IR) and (UV) Spectroscopy.

All of those compounds were screened for their anti-microbial activity in vitro.

The results show that most of the compounds A, B, C exhibited moderate to good activity against Gram-positive bacteria and the same compound exhibit low to moderate activity on most gram-negative bacteria under study.

Finally, compound E and F had little or no effect organism.