Effect of stem cells injection in adult male albino rats with streptozotocin-induced diabetic nephropathy
Joint Authors
Abd al-Hamid, Ala al-Din Sad
Dissassa, Kumlachew D.
Husayn, Muna A.
Ali, Muna Hasan
Source
Suez Canal University Medical Journal
Issue
Vol. 16, Issue 1 (30 Jun. 2013), pp.52-61, 10 p.
Publisher
Suez Canal University Faculty of Medicine
Publication Date
2013-06-30
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Topics
Abstract EN
Background : Diabetic Nephropathy is a leading cause of end-stage renal disease and the most frequent cause of mortality in patients with diabetes.
Therefore, it is extremely important to identify novel interventions to halt the progression of diabetic nephropathy.
Aim : This study investigated the effect of human umbilical cord blood (HUCB) derived (CD34+) stem cells therapy on renal morphologic and functional changes and alterations of kidney enzyme levels in streptozotocin (STZ)-induced diabetic nephropathy in rats.
Materials and Methods : Sixty adult male albino rats were included in this study and were randomly and equally divided into three groups.
Group 'A' was the control, group 'B' was treated with STZ (65 mg / kg, IP) only and group 'C' was treated with STZ and HUCB CD34+ stem cells (1 x 106 cells / rat, IV).
Results : Intravenous injection of CD34 + cells caused significant improvement in blood glucose level (438.3 ± 67 mg / dl of group B vs.
141.8 ± 23.4 mg / dl of group C, p < 0.01).
Serum urea and creatinine levels were significantly lower of group C than group B.
The levels of alanine aminotransferase (ALT) and alkaline phosphatase (ALP) enzymes in the kidney tissues were significantly lower of group C than group B.
Histo-pathology of the kidney showed much better recovery of group C than group B.
Conclusion : HUCB CD34 + cells transplantation in diabetic rats is able to improve blood glucose level, partially amelio-rate the renal damage in diabetic rats and consequently improve renal function, renal histology and renal enzyme levels alteration.
American Psychological Association (APA)
Dissassa, Kumlachew D.& Ali, Muna Hasan& Husayn, Muna A.& Abd al-Hamid, Ala al-Din Sad. 2013. Effect of stem cells injection in adult male albino rats with streptozotocin-induced diabetic nephropathy. Suez Canal University Medical Journal،Vol. 16, no. 1, pp.52-61.
https://search.emarefa.net/detail/BIM-380622
Modern Language Association (MLA)
Dissassa, Kumlachew D.…[et al.]. Effect of stem cells injection in adult male albino rats with streptozotocin-induced diabetic nephropathy. Suez Canal University Medical Journal Vol. 16, no. 1 (2013), pp.52-61.
https://search.emarefa.net/detail/BIM-380622
American Medical Association (AMA)
Dissassa, Kumlachew D.& Ali, Muna Hasan& Husayn, Muna A.& Abd al-Hamid, Ala al-Din Sad. Effect of stem cells injection in adult male albino rats with streptozotocin-induced diabetic nephropathy. Suez Canal University Medical Journal. 2013. Vol. 16, no. 1, pp.52-61.
https://search.emarefa.net/detail/BIM-380622
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 59-61
Record ID
BIM-380622