Inhibition of Angiogenesis In Vitro by Chebulagic Acid : A COX-LOX Dual Inhibitor
Joint Authors
Sudhakaran, P. R.
Khidr, Saja Diya
Athira, A. P.
Reddanna, P.
Helen, A.
Source
International Journal of Vascular Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Angiogenesis is a crucial step in the growth of cancer and its metastasis.
It is regulated by several endogenous factors which may stimulate or inhibit the new blood vessel growth.
Besides these endogenous factors, several exogenous factors including some natural compounds are known to modulate angiogenesis.
Angiogenesis being a potential target for drugs against a number of pathological conditions, search for compounds from natural sources that can affect angiogenesis is of great interest.
The objective of our present study was to understand the effect of chebulagic acid, a COX-LOX dual inhibitor isolated from the fruits of Terminalia chebula Retz., on angiogenesis.
The model systems used were rat aortic rings and human umbilical vein endothelial cells.
The results showed that chebulagic acid exerts an antiangiogenic effect.
This was evidenced from decreased sprouting in rat aortic rings and decrease in biochemical markers in endothelial cells treated with chebulagic acid.
It downregulated the production of CD31, E-selectin, and vascular endothelial growth factor in human umbilical vein endothelial cells in culture (HUVEC).
Further studies to understand the molecular mechanism of action of chebulagic acid revealed that CA exerts its anti angiogenic effect by modulating VE cadherin-β catenin signalling in human umbilical vein endothelial cells.
American Psychological Association (APA)
Athira, A. P.& Helen, A.& Khidr, Saja Diya& Reddanna, P.& Sudhakaran, P. R.. 2013. Inhibition of Angiogenesis In Vitro by Chebulagic Acid : A COX-LOX Dual Inhibitor. International Journal of Vascular Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502753
Modern Language Association (MLA)
Athira, A. P.…[et al.]. Inhibition of Angiogenesis In Vitro by Chebulagic Acid : A COX-LOX Dual Inhibitor. International Journal of Vascular Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-502753
American Medical Association (AMA)
Athira, A. P.& Helen, A.& Khidr, Saja Diya& Reddanna, P.& Sudhakaran, P. R.. Inhibition of Angiogenesis In Vitro by Chebulagic Acid : A COX-LOX Dual Inhibitor. International Journal of Vascular Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-502753
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-502753