Gentamycin-induced nephrotoxicity in chickens : modulatory role of moringa oleifera
Other Title(s)
التسمم الكلوي بالجنتاميسين في الدجاج و التأثير الوقائي للمور ينجا
Joint Authors
Abu al-Azab, Muhammad Fahmi
al-Habashi, Najwan Mahmud
Source
Assiut Veterinary Medical Journal
Issue
Vol. 61, Issue 144 (31 Jan. 2015), pp.104-112, 9 p.
Publisher
Assiut University Faculty of Veterinary Medicine
Publication Date
2015-01-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
Abstract AR
استخدمت عشرين دجاجة من الدجاج البياض في هذه الدراسة لتقييم دور المور ينجا في تحسين التأثير السمي للجنتامسين من خلال دراسة وظائف الكلي و مضادات الأكسدة و النتائج الهستوباثولوجية للدجاج.
قسم الدجاج إلى أربع مجموعات، مجموعة ضابطة بدون الجنتاميسين أو المور ينجا، و مجموعة المور ينجا بدون جفتاميسين، و مجموعة الجفتاميسين بدون المور ينجا، و مجموعة المور ينجا المعرضة للتسمم بالجنتاميسين أشارت النتائج إلى زيادة الكرياتينين (CR)، اليوريا نيتروجين في الدم (BU)، و المالون الدهيد MDA) malonaldehyde) و انخفض البروتين الكلي و الألبومن و مضادات الأكسدة في مجموعة الجنتاميسين كما أن استخدام المور ينجا أدى إلى تحسين وظائف الكلي و مضادات الأكسدة و تقليل الأثار الهسوباثولوجية الضارة للجنتاميسين.
Abstract EN
The aim of the present study was to determine whether Moringa oleifera (MOR) leaf powder, have a modulatory effect against gentamicin (GEN)-induced nephrotoxicity in chickens or not.
Twenty laying hens were equally divided into four groups: First group (CON) received standard basal diet only.
Second group (GEN) was injected with GEN (50 mg / kg body weight, intramuscularly (i.m.), twice daily, for 5 consecutive days).
Third group (GEN + MOR) was supplemented with MOR leaf powder (10 gm / kg diet) daily for 12 consecutive days and injected with GEN (50 mg / kg body weight, i.m., twice daily, for 5 consecutive days) starting from the day 8.
Fourth group (MOR) was supplemented with MOR leaf powder (10 gm / kg diet) daily for 12 consecutive days.
GEN administration increased serum creatinine (Cr), blood urea nitrogen (BUN), and malonaldehyde (MDA) and decreased total protein, albumin, reduced glutathione (GSH) content as well as superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) activities indicating nephrotoxicity.
Furthermore, histopathological findings revealed marked tubular vacuolar degeneration, focal interstitial mononuclear cells infiltrations, congestion, focal cystic change and tubular necrosis in GEN-treated kidneys.
However, MOR leaf powder supplementation with GEN administration caused significant decrease of serum Cr, BUN, and MDA and increase of total protein, albumin, GSH, SOD, GPx, and CAT compared with GEN alone.
Moreover, GEN + MOR treated group showed slight focal interstitial mononuclear cells infiltrations in renal tissues.
These findings suggested that dietary supplementation of MOR leaf powder may prevent or reduce the GEN-induced nephrotoxicity.
American Psychological Association (APA)
Abu al-Azab, Muhammad Fahmi& al-Habashi, Najwan Mahmud. 2015. Gentamycin-induced nephrotoxicity in chickens : modulatory role of moringa oleifera. Assiut Veterinary Medical Journal،Vol. 61, no. 144, pp.104-112.
https://search.emarefa.net/detail/BIM-530107
Modern Language Association (MLA)
Abu al-Azab, Muhammad Fahmi& al-Habashi, Najwan Mahmud. Gentamycin-induced nephrotoxicity in chickens : modulatory role of moringa oleifera. Assiut Veterinary Medical Journal Vol. 61, no. 144 (Jan. 2015), pp.104-112.
https://search.emarefa.net/detail/BIM-530107
American Medical Association (AMA)
Abu al-Azab, Muhammad Fahmi& al-Habashi, Najwan Mahmud. Gentamycin-induced nephrotoxicity in chickens : modulatory role of moringa oleifera. Assiut Veterinary Medical Journal. 2015. Vol. 61, no. 144, pp.104-112.
https://search.emarefa.net/detail/BIM-530107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 110-112
Record ID
BIM-530107