Synthesis and antibacterial evaluation of some new Azo-pyrazoline compounds derived from p-aminoacetophenone

الملخص EN

A series of new substituted azo-pyrazolinecompounds have been synthesized and evaluated for their in vitro antimicrobial activity along with standard ciprofloxacin against gram positive Staphylococcus aureus and gram negative Klebsiellapneumoniae.

The preparation of the newly azo-pyrazolinecompounds have been started by the direct diazotization of p-aminoacetophenone with o-cresol as an active coupling agent.

The prepared azo-acetophenone(1) was benzylated with p-chlorobenzylchloride to give benzyloxy-azochalcones (2).

The later compound was reacted with a series of substituted benzaldehydesgiving a new chalcones(3a-j), which were cyclized to new pyrazolines(4a-j) by the treatment with phenylhydrazin.

Finally the structures of the synthesized compounds were confirmed spectroscopically using FT-IR, 1H-NMR, 13C-NMR and 13C- DEPT-135 spectra.