New mode for the on-line determination of metoclopramide hydrochloride in pure and pharmaceutical preparations via the use of homemade ayah 6SX1-T-2D solar cell CFI analyser

Abstract EN

A newly developed analytical method characterized by its speed and sensitivity for the determination of metoclopramide hydrochloride (MCP-HCl) in pure and pharmaceutical preparations via absorbance measurement by Ayah 6SX1-T-2D Solar cell-CFI Analyser.

The method is based on the oxidation of the drug with Ce(IV)sulfate in acidic medium to form a red color species which determined using homemade Ayah 6SX1-T-2D Solar cell .

Chemical and physical parameters were studied and optimized.

The calibration graph was linear in the range of 0.05- 16 mMol.L-1with correlation coefficient r = 0.9855.

The limit of detection(S / N = 3) 0.332 μg/sample from the step wise dilution for the minimum concentration in the linear dynamic ranged of the calibration graph.

The RSD% at 2 and 6mMol.L-1 metoclopramide hydrochloride is less than 0.6% (six replicate).

The method was successfully applied for the determination of metoclopramide hydrochloride in three pharmaceutical drugs.

A comparison was made between the newly developed method analysis with the classical method (UV-Vis spectrophotometry at λ max 474 nm) using the standard addition method via the use of ttest.

It was noticed that there was a significant difference between two methods at 95 % confidence level.