Micronucleus formation and sister chromatid exchange in female lymphocytes associated with recurrent spontaneous abortion
Joint Authors
al-Faysal, Abd al-Husayn Muwayt
Nada, Sad Muhammad
Mahud, Rasha Abd al-Husayn
Source
Iraqi Journal of Biotechnology
Issue
Vol. 14, Issue 2 (31 Dec. 2015), pp.21-29, 9 p.
Publisher
University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
This study aimed to assess possible genomic instability in women with recurrent spontaneous abortion (RSA).
Sixty four blood samples from women complaining with RSA and 41 normal fertile females, who had at least one or more child, 21 of them were pregnant women while 20 non-pregnant were collected.
Frequency of micronuclei (MN) in Women with RSA was statistically increased (8.66+1.74) (p < 0.05) compared with normal fertile women either pregnant (3.83 + 0.74) or non-pregnant (3.61+1.02).
The difference between non-pregnant and normal pregnant groups was not significant.
The results obtained from SCE analysis were used to detect DNA damage among RSA women and control.
The result showed a significant increase (P < 0.05) in SCE frequency in women with RSA (8.43 + 2.65) compared with normal control either non-pregnant (3.85+0.97) or pregnant women (3.52 + 0.94), with no significant differences between them.
This concluded that the frequency of MN and SCE in cultured peripheral lymphocytes can be used as a biomarker of genomic instability in somatic cells.
American Psychological Association (APA)
al-Faysal, Abd al-Husayn Muwayt& Nada, Sad Muhammad& Mahud, Rasha Abd al-Husayn. 2015. Micronucleus formation and sister chromatid exchange in female lymphocytes associated with recurrent spontaneous abortion. Iraqi Journal of Biotechnology،Vol. 14, no. 2, pp.21-29.
https://search.emarefa.net/detail/BIM-644687
Modern Language Association (MLA)
al-Faysal, Abd al-Husayn Muwayt…[et al.]. Micronucleus formation and sister chromatid exchange in female lymphocytes associated with recurrent spontaneous abortion. Iraqi Journal of Biotechnology Vol. 14, no. 2 (2015), pp.21-29.
https://search.emarefa.net/detail/BIM-644687
American Medical Association (AMA)
al-Faysal, Abd al-Husayn Muwayt& Nada, Sad Muhammad& Mahud, Rasha Abd al-Husayn. Micronucleus formation and sister chromatid exchange in female lymphocytes associated with recurrent spontaneous abortion. Iraqi Journal of Biotechnology. 2015. Vol. 14, no. 2, pp.21-29.
https://search.emarefa.net/detail/BIM-644687
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 28-29
Record ID
BIM-644687