Molecular study of azithromycin-resistant P. aeruginosa

Joint Authors

al-Rabii, Dalal S.
al-Bassam, Wasan Wail Muhammad Ali
Hamud, Muhammad Ab. L.
al-Rabii, Ilham Abd al-Hadi Khalaf

Source

Iraqi Journal of Biotechnology

Issue

Vol. 14, Issue 2 (31 Dec. 2015), pp.71-79, 9 p.

Publisher

University of Baghdad Genetic Engineering and Biotechnology for Postgraduate Studies

Publication Date

2015-12-31

Country of Publication

Iraq

No. of Pages

9

Main Subjects

Biology

Topics

Abstract EN

The aim of the present study was to investigate the occurrence of azithromycin resistance among P.

aeruginosa swabs isolates.

Out of 60 pus, burn and wound swabs, 16 (26.6%) P.

aeruginosa were isolated.

The susceptibilities of the P.

aeruginosa isolates to the macrolides azithromycin, chloramphenicol and aminoglycosides streptomycin, gentamicin and kanamycin were evaluated by disc diffusion experiments.

The azithromycin was observed to be less resistance with high susceptibilities rate 13 (81.25) as compared to aminoglycosides and chloramphenicol.

Partial 23S rDNA gene sequences of 12 isolates demonstrate new single base substitution in the resistant isolates in positions A1807G, C1808A, A1823G and A1819G which confer the azithromycin resistance with low frequency rate 0.9 for each one.

As we recommend the azithromycin is the drug of choice in P.

aeruginosa treatment, further study is needed to whole 23S rDNA gene in local isolates to identify mutations outside the partial selected region.

American Psychological Association (APA)

al-Rabii, Dalal S.& al-Bassam, Wasan Wail Muhammad Ali& Hamud, Muhammad Ab. L.& al-Rabii, Ilham Abd al-Hadi Khalaf. 2015. Molecular study of azithromycin-resistant P. aeruginosa. Iraqi Journal of Biotechnology،Vol. 14, no. 2, pp.71-79.
https://search.emarefa.net/detail/BIM-644774

Modern Language Association (MLA)

al-Rabii, Dalal S.…[et al.]. Molecular study of azithromycin-resistant P. aeruginosa. Iraqi Journal of Biotechnology Vol. 14, no. 2 (2015), pp.71-79.
https://search.emarefa.net/detail/BIM-644774

American Medical Association (AMA)

al-Rabii, Dalal S.& al-Bassam, Wasan Wail Muhammad Ali& Hamud, Muhammad Ab. L.& al-Rabii, Ilham Abd al-Hadi Khalaf. Molecular study of azithromycin-resistant P. aeruginosa. Iraqi Journal of Biotechnology. 2015. Vol. 14, no. 2, pp.71-79.
https://search.emarefa.net/detail/BIM-644774

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 78-79

Record ID

BIM-644774