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Evaluating molecular study of the association of glutathione S–transferase GST (T1, M1) genetic polymorphism in Iraqi Arab femals with Type 2 diabetes mellitus and coronary artery disease
Other Title(s)
تقييم الدراسة الجزيئية للعلاقة بين الجلوتاثيون اس-ترانسفييز (T1, M1) في الإناث العراقيات العربيات مصابات بداء السكري من النوع الثاني و إمراض الشرايين القلبية التاجية
Joint Authors
Mahmud, Marwah Muhyi al-Din
al-Isa, Nagham Isa
al-Karawi, Isam Nuri Salman
Shihab, Batul Ali
Source
Issue
Vol. 12, Issue 4 (31 Dec. 2015), pp.715-723, 9 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2015-12-31
Country of Publication
Iraq
No. of Pages
9
Main Subjects
Topics
Abstract EN
Coronary artery disease (CAD) is a major health concern and leading of death in individuals with type 2 diabetes mellitus (T2DM).
Glutathione S – Transferase(GST) are known for their broad range of detoxification and in the metabolism of xenobiotics .
The role of functional variants of these genes in the development of various disorder is proven.
We investigated the possible role of these variants in the development of CAD in T2DM patients.
In this case – control study a total of 60 patients (T2DM = 30 ; T2DM – CAD = 30) and 30 controls were included.
Serum lipid profiles were measured and DNA was extracted from the blood samples.
Multiplex PCR for GSTT1/M1 (present / null) polymorphism, were performed for genotyping of study participants.
Gene frequency and lipid profiles were statistically analyzed for disease association.
Regression analysis showed that, there was no significant difference of the frequency of GSTT1 (positive /null) genotype and GSTM1 (positive /null) genotype in the 3 study groups .
GSTT1 – positive genotype is associated with a 0.51 fold increased ( OR = 0.51 ; 95%CI = 2- 0.1 ;P = 0.321 ) , while the GSTM1 – positive genotype was associated with a 3 fold increase ( OR = 3.06 ; 95%CI=1- 9.7 ; P = 0.055) .We conclude GSTT1 positive genotype considered to be a protective risk from CAD in T2DM patients .
The GSTM1 – positive genotype it was considered to be a risk factor of the CAD in T2DM patients.
American Psychological Association (APA)
Mahmud, Marwah Muhyi al-Din& al-Isa, Nagham Isa& al-Karawi, Isam Nuri Salman & Shihab, Batul Ali. 2015. Evaluating molecular study of the association of glutathione S–transferase GST (T1, M1) genetic polymorphism in Iraqi Arab femals with Type 2 diabetes mellitus and coronary artery disease. Baghdad Science Journal،Vol. 12, no. 4, pp.715-723.
https://search.emarefa.net/detail/BIM-654389
Modern Language Association (MLA)
Mahmud, Marwah Muhyi al-Din…[et al.]. Evaluating molecular study of the association of glutathione S–transferase GST (T1, M1) genetic polymorphism in Iraqi Arab femals with Type 2 diabetes mellitus and coronary artery disease. Baghdad Science Journal Vol. 12, no. 4 (2015), pp.715-723.
https://search.emarefa.net/detail/BIM-654389
American Medical Association (AMA)
Mahmud, Marwah Muhyi al-Din& al-Isa, Nagham Isa& al-Karawi, Isam Nuri Salman & Shihab, Batul Ali. Evaluating molecular study of the association of glutathione S–transferase GST (T1, M1) genetic polymorphism in Iraqi Arab femals with Type 2 diabetes mellitus and coronary artery disease. Baghdad Science Journal. 2015. Vol. 12, no. 4, pp.715-723.
https://search.emarefa.net/detail/BIM-654389
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 720-722
Record ID
BIM-654389