Rectal diclofenac versus rectal paracetamol : comparison of antipyretic effectiveness in children
Joint Authors
Sharif, Muhammad Rida
Ridai, Mustafa Haji
Aalinezhad, Marzieh
Sarami, Golbahareh
Rangraz, Masud
Source
Iranian Red Crescent Medical Journal
Issue
Vol. 18, Issue 1 (31 Jan. 2016), pp.1-7, 7 p.
Publisher
Publication Date
2016-01-31
Country of Publication
United Arab Emirates
No. of Pages
7
Main Subjects
Topics
Abstract EN
Background : Fever is the most common complaint in pediatric medicine and its treatment is recommended in some situations.
Paracetamol is the most common antipyretic drug, which has serious side effects such as toxicity along with its positive effects.
Diclofenac is one of the strongest non-steroidal anti-inflammatory (NSAID) drugs, which has received little attention as an antipyretic drug.
Objectives : This study was designed to compare the antipyretic effectiveness of the rectal form of Paracetamol and Diclofenac.
Patients and Methods: This double-blind controlled clinical trial was conducted on 80 children aged six months to six years old.
One group was treated with rectal Paracetamol suppositories at 15 mg / kg dose and the other group received Diclofenac at 1 mg/kg by rectal administration (n = 40).
Rectal temperature was measured before and one hour after the intervention.
Temperature changes in the two groups were compared.
Results : The average rectal temperature in the Paracetamol group was 39.6 ± 1.13°C, and 39.82 ± 1.07°C in the Diclofenac group (P = 0.37).
The average rectal temperature, one hour after the intervention, in the Paracetamol and the Diclofenac group was 38.39 ± 0.89°C and 38.95 ± 1.09°C, respectively (P = 0.02).
Average temperature changes were 0.65 ± 0.17°C in the Paracetamol group and 1.73 ± 0.69°C in the Diclofenac group (P < 0.001).
Conclusions : In the first one hour, Diclofenac suppository is able to control the fever more efficient than Paracetamol suppositories.
American Psychological Association (APA)
Sharif, Muhammad Rida& Ridai, Mustafa Haji& Aalinezhad, Marzieh& Sarami, Golbahareh& Rangraz, Masud. 2016. Rectal diclofenac versus rectal paracetamol : comparison of antipyretic effectiveness in children. Iranian Red Crescent Medical Journal،Vol. 18, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-654849
Modern Language Association (MLA)
Sharif, Muhammad Rida…[et al.]. Rectal diclofenac versus rectal paracetamol : comparison of antipyretic effectiveness in children. Iranian Red Crescent Medical Journal Vol. 18, no. 1 (Jan. 2016), pp.1-7.
https://search.emarefa.net/detail/BIM-654849
American Medical Association (AMA)
Sharif, Muhammad Rida& Ridai, Mustafa Haji& Aalinezhad, Marzieh& Sarami, Golbahareh& Rangraz, Masud. Rectal diclofenac versus rectal paracetamol : comparison of antipyretic effectiveness in children. Iranian Red Crescent Medical Journal. 2016. Vol. 18, no. 1, pp.1-7.
https://search.emarefa.net/detail/BIM-654849
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 6-7
Record ID
BIM-654849