Evaluation of immune response to brucella infection in sheep
Other Title(s)
تقييم الاستجابة المناعية لداء البروسيلا في الأغنام
Joint Authors
Suwayyiḥ, Akram Mutlaq
al-Hatimi, Abd Allah O.
Muhammad, Karim Ghali
Source
Kufa Journal for Veterinary Medical Sciences
Issue
Vol. 6, Issue 1 (30 Jun. 2015), pp.22-29, 8 p.
Publisher
University of Kufa Faculty of Veterinary Medicine
Publication Date
2015-06-30
Country of Publication
Iraq
No. of Pages
8
Main Subjects
Topics
Abstract EN
Brucellosis in sheep and goats is a zoonotic infection (excluding Brucella ovis) with important effects on both public health and animal health.
The disease is widespread in many areas of the world, particularly in some Mediterranean and Middle Eastern countries.
Aim of the study: the present study aims to find out the prevalence of brucellosis in sheep in one of the areas of An Najaf El-Ashraf city, and study of the immune response by measuring the levels of and interleukin-10 (IL-10).
Methodology: Current study conducted in the Najaf province (Al-Barakyia) during the period between September 2013- March 2014, fulfilled by using Rose Bengal and Enzyme Immunosorbent Assay (ELISA) tests for estimation of brucella antibodies.
A total number of 48 serum samples were collected from sheep and stored at -20°C.
Results: the frequency of positive sera by Rose Bengal test (RBT) was 20% and by ELISA technique was 25%.
The level of interleukin 10 (IL-10) was estimated in all surveyed animals, 12 sera samples were showed an elevated IL-10 levels, all were positive with ELISA serological test.
Conclusion: the detection of significant concentration of IL-10 among the seropositive cases may be indicated an active infection of brucella with type 2 cytokine production.
Recommendations: the evaluation of immune response of vaccinated sheep with brucella REV1 vaccine, depending on the estimation of IFN-γ and IL-10 ratio that will reflect the cytokines induced during vaccination and consequently, the effective or not immune response.
American Psychological Association (APA)
Muhammad, Karim Ghali& al-Hatimi, Abd Allah O.& Suwayyiḥ, Akram Mutlaq. 2015. Evaluation of immune response to brucella infection in sheep. Kufa Journal for Veterinary Medical Sciences،Vol. 6, no. 1, pp.22-29.
https://search.emarefa.net/detail/BIM-655892
Modern Language Association (MLA)
Muhammad, Karim Ghali…[et al.]. Evaluation of immune response to brucella infection in sheep. Kufa Journal for Veterinary Medical Sciences Vol. 6, no. 1 (Jun. 2015), pp.22-29.
https://search.emarefa.net/detail/BIM-655892
American Medical Association (AMA)
Muhammad, Karim Ghali& al-Hatimi, Abd Allah O.& Suwayyiḥ, Akram Mutlaq. Evaluation of immune response to brucella infection in sheep. Kufa Journal for Veterinary Medical Sciences. 2015. Vol. 6, no. 1, pp.22-29.
https://search.emarefa.net/detail/BIM-655892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 27-29
Record ID
BIM-655892