Effect of Artemisia judaica ethanolic extract on skin inflammation and hematological and biochemical characteristics of blood in rats
Other Title(s)
تأثير المستخلص الايثانولي لنبات البعيثران على الالتهابات الجلدية و الخصائص الدموية و البيوكيمائية للدم في الجرذان
Dissertant
Thesis advisor
Comitee Members
al-Shurafa, Khalid Yusuf Ahmad
Khulayfat, Khalid Muhammad
al-Laymun, Muhammad Awdah
University
Mutah University
Faculty
Faculty of Science
Department
Department of Biological Sciences
University Country
Jordan
Degree
Master
Degree Date
2015
English Abstract
The effect of oral administration of ethanolic extract of the whole plant of Artemisia judaica on hematological and biochemical parameters were investigated in male albino rats.
This study was intended to evaluate the anti-inflammatory activity in carrageenan induced paw edema.
Rats were divided into two groups, control group and treated group.
The treated rats were orally given 270 mg/kg body weight of ethanolic extract of A.
judaica for 4 weeks.
For anti-inflammatory activity test, both groups were injected with 0.1 ml of 1% lambda carrageenan in saline , and the degree of paw edema was assessed.
The results of the present study showed a non significant (P>0.05) change in RBCs count, hematocrit, serum levels of cholesterol, aspartate aminotranferase (ASAT), alkaline phosphotase (ALP), creatine kinase (CK) and uric acid.
Other parameters including glucose, triglyceride and urea were significantly (P<0.05) decreased as compared to control rats.
However, serum alanine aminotransferase (ALAT) levels were significantly increased (P<0.05).
The present results showed that total WBCs count and hemoglobin percentage were significantly (P<0.05) increased as compared to control rats.
On the other hand the ethanolic extract of A.
judaica showed inhibition on carrageenan induced rat paw edema, the thickness was significantly (P<0.05) increased as compared to control paw (saline).
It is concluded that chronic treatment with ethanolic extract of A.
judaica induces significant changes in some hematological and biochemical parameters of the rat blood.
In addition the ethanolic extract of A.
judaica showed significantly anti-inflammatory activity in the rat skin.
Main Subjects
Topics
No. of Pages
36
Table of Contents
Table of contents.
Abstract.
Abstract in Arabic.
Chapter One : Theoretical background.
Chapter Two : Literature review.
Chapter Three : Materials and methods.
Chapter Four : Results, discussion and conclusion.
References.
American Psychological Association (APA)
Karjaghli, Darin Husayn. (2015). Effect of Artemisia judaica ethanolic extract on skin inflammation and hematological and biochemical characteristics of blood in rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-656389
Modern Language Association (MLA)
Karjaghli, Darin Husayn. Effect of Artemisia judaica ethanolic extract on skin inflammation and hematological and biochemical characteristics of blood in rats. (Master's theses Theses and Dissertations Master). Mutah University. (2015).
https://search.emarefa.net/detail/BIM-656389
American Medical Association (AMA)
Karjaghli, Darin Husayn. (2015). Effect of Artemisia judaica ethanolic extract on skin inflammation and hematological and biochemical characteristics of blood in rats. (Master's theses Theses and Dissertations Master). Mutah University, Jordan
https://search.emarefa.net/detail/BIM-656389
Language
English
Data Type
Arab Theses
Record ID
BIM-656389
