Synthesis of novel nucleoside analogues from imidizoline and evaluation their anti microbial activity
Other Title(s)
تحضير مماثلات نيكلوسيدات جديدة و تقييم فعاليتها ضد الميكروبات
Joint Authors
al-Mumin, Thana Mahdi Abd al-Karim
Mahdi, Diya Jabbar
Source
Issue
Vol. 57, Issue 1A (31 Mar. 2016), pp.14-27, 14 p.
Publisher
University of Baghdad College of Science
Publication Date
2016-03-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Topics
Abstract EN
In this research some new nucleoside analogues were synthesized.
Starting from α-D- glucose which was protected to glucose penta acetat α-D- glucose pyronside (1).
Which was converted to active form 1-bromo protected sugar (2) as a sugar moiety.
The base moiety 2-substituted imidazoline (3,4) was prepared from condensation of ethylene diamine with two kind of aromatic aldehydes, which were subjected to amino alkylation via Mannich reaction forming new nucleaobase derivatives (5-10).
Condensation of nucleobase with bromo sugar through nucleophilic substitution of anomeric carbon with nitrogen forming new protected nucleoside analogues (11-16).
De blocking of these nucleoside analogues with sodium methoxide in methanol afforded our target the free nucleoside analogues (17-22).All prepared compounds were identified by FT-IR and some of them with 1H-NMR and 13C-NMR spectroscopy.
Some of synthesized nucleoside analogues were screened for their antibacterial activity against four types of bacteria, also against four types of fungi.
American Psychological Association (APA)
al-Mumin, Thana Mahdi Abd al-Karim& Mahdi, Diya Jabbar. 2016. Synthesis of novel nucleoside analogues from imidizoline and evaluation their anti microbial activity. Iraqi Journal of Science،Vol. 57, no. 1A, pp.14-27.
https://search.emarefa.net/detail/BIM-689654
Modern Language Association (MLA)
al-Mumin, Thana Mahdi Abd al-Karim& Mahdi, Diya Jabbar. Synthesis of novel nucleoside analogues from imidizoline and evaluation their anti microbial activity. Iraqi Journal of Science Vol. 57, no. 1A (2016), pp.14-27.
https://search.emarefa.net/detail/BIM-689654
American Medical Association (AMA)
al-Mumin, Thana Mahdi Abd al-Karim& Mahdi, Diya Jabbar. Synthesis of novel nucleoside analogues from imidizoline and evaluation their anti microbial activity. Iraqi Journal of Science. 2016. Vol. 57, no. 1A, pp.14-27.
https://search.emarefa.net/detail/BIM-689654
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 26-27
Record ID
BIM-689654