Synthesis of some new nucleoside analogues containing seven membered ring and studying their biological activity
Other Title(s)
تحضير بعض نظائر النيوكليوسيدات الجديدة المرتبطة بحلقة سباعية و دراسة فعاليتها البايلوجية
Joint Authors
Muhammad, Umar Abd al-Latif
al-Mumin, Thana Mahdi Abd al-Karim
Muhammad, Yasamin Hikmat
Mahdi, Surur Abd al-Rahman
Source
Issue
Vol. 13, Issue 3 (30 Sep. 2016), pp.531-546, 16 p.
Publisher
University of Baghdad College of Science for Women
Publication Date
2016-09-30
Country of Publication
Iraq
No. of Pages
16
Main Subjects
Topics
Abstract EN
In this work, a series of new Nucleoside analogues (D-galactopyranose linked to oxepanebenzimidazole moiety) was synthesized via multisteps synthesis.
The first step involved preparation of two benzimidazoles 2-styrylbenzimidazole and 2-(phenyl ethynyl) benzimidazole via reaction of phenylenediamine with cinnamic acid or β-phenyl propiolic acid.
Electrophilic addition of the prepared benzimidazoles by three anhydrides in the second step afforded (4-6) and (14-16) which in turn were treated with 1,2,3,4-di-O-isopropylidene galactopyranose in the third step to afford a series of the desirable protected nucleoside analogues (7-9) ,(17-19)which after hydrolysis in methanolic sodium methoxidein the fourth step afforded the free nucleoside analogues (10-12) and (20-22) .The synthesized compounds were identified by FT-IR and some of them by 1H-NMR and13C-NMR.
The synthesized oxepane nucleoside analogues were screened for their antibacterial activity against three types of bacteria including Staphylococcusaureus ,Bacillus(gram positive) andE.coli (gram negative) bacteria repectively.
American Psychological Association (APA)
al-Mumin, Thana Mahdi Abd al-Karim& Mahdi, Surur Abd al-Rahman& Muhammad, Umar Abd al-Latif& Muhammad, Yasamin Hikmat. 2016. Synthesis of some new nucleoside analogues containing seven membered ring and studying their biological activity. Baghdad Science Journal،Vol. 13, no. 3, pp.531-546.
https://search.emarefa.net/detail/BIM-722415
Modern Language Association (MLA)
al-Mumin, Thana Mahdi Abd al-Karim…[et al.]. Synthesis of some new nucleoside analogues containing seven membered ring and studying their biological activity. Baghdad Science Journal Vol. 13, no. 3 (2016), pp.531-546.
https://search.emarefa.net/detail/BIM-722415
American Medical Association (AMA)
al-Mumin, Thana Mahdi Abd al-Karim& Mahdi, Surur Abd al-Rahman& Muhammad, Umar Abd al-Latif& Muhammad, Yasamin Hikmat. Synthesis of some new nucleoside analogues containing seven membered ring and studying their biological activity. Baghdad Science Journal. 2016. Vol. 13, no. 3, pp.531-546.
https://search.emarefa.net/detail/BIM-722415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 544-545
Record ID
BIM-722415